Fractional Laser or Chemical Peel in Older Skin to See IGF-1 Changes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study compares two skin-wounding approaches—fractional non-ablative laser and a trichloroacetic acid (TCA) chemical peel—to see if they elicit a rise in IGF-1 levels in aged, sun-damaged skin. It aims to determine feasibility and whether these methods can produce effects similar to fractional ablative lasers at three months. Researchers will evaluate safety, wound healing, and IGF-1 changes after treatment. Eligible participants are adults over 55 with photodamage who are not on medications that impair wound healing and have no prior recent laser or peel treatments in the target area.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female subjects \>55 years old
* Fitzpatrick type I-II
* Able to provide informed consent.
* Cutaneous photodamage of 3 or above on the Larnier photodamage scale (see Appendix).

Exclusion Criteria:

* Prior laser or peel treatment in the area evaluated in the current study in the past year.
* Currently taking immunosuppressant medications known to interfere wound healing or anti-inflammatory medications (such as NSAIDs, or steroids).
* Subjects who have underlying diseases that could alter wound healing response (such as Diabetes).
* Currently taking insulin.
* History of substance abuse, mental dysfunction, or other factors limiting ability to cooperate with study.
* History of abnormal scarring such as Keloids.
* History of vitiligo.
* Allergy or sensitivity or allergy to topical anesthesia
* Inability to use sunscreen.
* History of smoking in the last 10 years
* Scar or prior surgery in the area of treatment.
* Use of isotretinoin in the prior 6 months
* Subjects who have bleeding disorders or who are taking anticoagulants

Where it's running

• Massachusetts General Hospital Clinical Unit for Research Trials and Outcomes in Skin
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Molly Wanner, MD
• Email: mwanner@mgh.harvard.edu
• Phone: 617-726-5066

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.