Examining skin responses to UV light in day and night shift workers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how the skin of night shift workers reacts to artificial sunlight, specifically ultraviolet B (UVB) radiation, compared to day shift workers. Participants will undergo skin biopsies, which will then be exposed to UVB in a laboratory setting to measure the skin's response. The research aims to understand the potential differences in DNA repair activity in the skin based on work schedules. This could provide insights into skin cancer risks associated with different work shifts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male/Female
* Fair skin (Fitzpatrick types I and II)
* Age 18 to 40
* Able to comprehend procedures/risks
* Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule.

Exclusion Criteria:

* Known photosensitivity
* Currently on photosensitizing medications
* Diabetes Mellitus
* On any hormonal agents (e.g., birth control pills)
* History of abnormal scarring
* History of skin infections
* History of skin cancers
* History of sleep disorders such as sleep apnea or insomnia
* Known allergy to lidocaine local anesthetic
* Pregnancy or nursing
* Other serious health issues

Where it's running

• Wright State Physicians
  Fairborn, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jeffrey B Travers, MD, PhD — Wright State University
• Study coordinator: Manager, Clinical Research Operations
• Email: pturesearch@wrightstatephysicians.org
• Phone: 937-245-7500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.