Condition

Postpartum Depression clinical trials and research

• 28Clinical trials
• 36NIH research projects
• 1New in 30 days
• 11Countries

Newest Postpartum Depression clinical trials

All recruiting trials (28)

• Smartphone-supported single-session psychotherapy for postpartum depression

  A single online therapy session plus four weeks of app-based support is being tested to see if it reduces depressive symptoms in postpartum women compared with a waitlist.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07925762

• Midwife-Led Digital Follow-Up After Cesarean Delivery

  This trial tests whether a midwife-led, four-week digital follow-up after cesarean delivery improves mood, social support, and breastfeeding confidence compared with standard postpartum care.

  Recruiting Inonu University · Giresun · NCT07523932

• Tracking postpartum depression symptoms after starting zuranolone

  This study will see how postpartum depression symptoms change in people who start taking zuranolone within a year after giving birth.

  Recruiting Biogen · Cambridge, Massachusetts · NCT07398469

• Non-invasive zinc protoporphyrin screening for iron deficiency in pregnancy

  This project tests a handheld device that measures zinc protoporphyrin through the lower lip to detect iron deficiency in pregnant and recently postpartum people.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT07083492

• Postpartum Depression: A Digital Decision Support Tool for Providers

  A digital tool within the electronic health record helps clinicians identify patients at risk for postpartum depression and guide support on referrals and education.

  Recruiting at 3 sites Weill Medical College of Cornell University · Brooklyn, New York and 3 other locations · NCT06818734

• Empowering mothers to prevent postpartum depression

  This study is testing a new online program that helps first-time pregnant women use art to boost their mental health and reduce the risk of postpartum depression.

  Recruiting Ege University · Izmir · NCT06787300

• Understanding how ketamine works for pain and depression after cesarean delivery

  This study is testing how ketamine can help manage pain and depression in new mothers after a cesarean delivery compared to healthy men and women who are not pregnant.

  Recruiting Phase 1 University of Utah · Pittsburgh, Pennsylvania and 1 other locations · NCT06767566

• Testing a sleep intervention for expectant and new mothers

  This study is testing a new sleep program for expectant and new mothers to see if it can help them get better sleep during and after pregnancy.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT06737055

• Extended Kangaroo Mother Care for Mothers of Low Birthweight Infants

  This study tests if staying longer in a special Kangaroo Mother Care ward can help mothers of low birthweight babies feel less depressed after giving birth.

  Recruiting University of Alabama at Birmingham · Lusaka · NCT06545760

• Using a Smart Bassinet to Improve Maternal Sleep and Mental Health

  This study is testing if a Smart Bassinet can help new mothers and their babies sleep better, which might also improve the mothers' mental health after giving birth.

  Recruiting University of Colorado, Colorado Springs · Colorado Springs, Colorado · NCT06544941

• Support for new parents in the NICU

  This study tests whether having a doula to support new parents in the NICU can help reduce stress and anxiety for those with preterm infants, especially for families from low-income backgrounds.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06521398

• Exploring caregiver-infant relationships in the NICU

  This study looks at how the voices of parents and nurses affect the development of preterm infants in the NICU and how parents' mental health may play a role in this relationship.

  Recruiting Istituto per la Ricerca e l'Innovazione Biomedica · Messina · NCT06462638

• Vitamin B6 supplementation for preventing depression in pregnant women

  This study is testing if taking Vitamin B6 during pregnancy can help prevent depression after childbirth in pregnant women.

  Recruiting National Taiwan University Hospital · Taipei · NCT06445933

• Digital tool to support maternal mental health during pregnancy

  This study is testing a new app to see if it can help pregnant women feel better and support their mental health during pregnancy.

  Recruiting at 3 sites A Thousand Colibris, S.L · Barcelona, Catalonia and 2 other locations · NCT06442774

• Online prenatal CBT‑I program to improve sleep and reduce postpartum stress and depression risk

  This project will try an online cognitive behavioral sleep program for pregnant women with insomnia to see if better sleep lowers postpartum stress and depression.

  Recruiting at 2 sites University of Rome G. Marconi · Bologna, Bologna and 1 other locations · NCT06379074

• Integrated care for mothers and infants to improve postpartum health

  This study is testing a new care program for new moms and their babies to see if it can help reduce postpartum depression, anxiety, and health issues in the year after childbirth.

  Recruiting Ohio State University · Columbus, Ohio · NCT06277661

• Improving access to mental health support for pregnant and postpartum women

  This study is testing a new online mental health support program for pregnant and new moms who might be at risk for postpartum depression to see how well it works for different people.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06049433

• Mindfulness intervention for mothers and infants

  This study tests if a mindfulness program for mothers and their babies can help reduce postpartum depression and anxiety while strengthening their bond.

  Recruiting Tilburg University · Tilburg, North Brabant · NCT05830266

• Health-education program for gestational diabetes and perinatal depression

  This program will try short health-education clips and questionnaires to see if improving health behaviors reduces depressive symptoms in pregnant people with gestational diabetes.

  Recruiting National Taiwan University Hospital · Taipei · NCT05800509

• Parenting skills program for mothers with postpartum depression

  This study tests whether a parenting skills program can help mothers with postpartum depression feel better and improve their relationship with their babies.

  Recruiting University of Colorado, Denver · Denver, Colorado · NCT05772897

• Comparing in-person and virtual group therapy to prevent postpartum depression

  This study is testing whether a group therapy program delivered online or in-person can help prevent postpartum depression in pregnant women, especially those from disadvantaged backgrounds.

  Recruiting University of Denver · Denver, Colorado · NCT05766475

• Exploring how doulas help people with perinatal mood and anxiety disorders

  This study is testing whether having a specially trained doula can help people dealing with mood and anxiety issues during and after pregnancy feel better.

  Recruiting University of Montana · Missoula, Montana · NCT05763537

• Universal prevention of postpartum depression using the ROSE program

  This study is testing whether a program called ROSE can help prevent postpartum depression in all pregnant women, not just those at risk, by making it easier to access during prenatal care.

  Recruiting Michigan State University · Flint, Michigan · NCT05700760

• Online intervention for postpartum depression

  This study is testing an online program to help women with postpartum depression by comparing two different types of support: one focused on changing thoughts and behaviors and the other on boosting happiness and well-being.

  Recruiting Universidad Complutense de Madrid · Madrid, Pozuelo de Alarcón · NCT05676918

• Psychotherapy program for postpartum depression

  This study is testing a new online therapy program for new moms with postpartum depression to see if it can help them feel less isolated and improve their mood.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05585164

• At-home brain stimulation for depression during pregnancy

  This study is testing if a type of at-home brain stimulation can help pregnant people with moderate to severe depression feel better.

  Recruiting at 2 sites Women's College Hospital · Toronto, Ontario and 1 other locations · NCT05097586

• Mindfulness and Vitamin D for Mothers of Preterm Infants

  This study tests if an 8-week mindfulness program and vitamin D supplements can help mothers of preterm infants feel less stressed and improve the quality of their milk.

  Recruiting University of Idaho · Coeur d'Alene, Idaho · NCT04821544

• Preventing postpartum depression with estradiol treatment

  This study is testing if a skin patch with estradiol can help prevent postpartum depression in pregnant women who have a history of depression.

  Recruiting Phase 1/2 Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT04685148

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Group-based postpartum depression prevention: in-person vs. virtual delivery

  A large study is testing whether the ROSE group program delivered virtually to pregnant people is just as helpful as the in-person version in preventing postpartum depression.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-11606534

• Postpartum depression screening at well-child visits in Arkansas

  A study examines whether adding depression screening at baby visits in Arkansas improves detection and care for new mothers.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11550534

• Ketamine to reduce postpartum depression and pain after cesarean delivery

  This grant explores a ketamine approach to help new mothers after cesarean delivery feel better sooner and with less pain.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11509433

• Trajectories of Positive Motivation and Postpartum Depression Risk

  This project studies how brain reward function and daily mood patterns before and after birth relate to the risk of postpartum depression, with a focus on mothers and babies.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11458939

• ROSE Scale-Up: Expanding universal postpartum depression prevention for new mothers

  A national effort to roll out the ROSE prevention program to all new mothers, to see if universal use can reduce postpartum depression.

  NIH research Michigan State University · East Lansing, United States · NIH-11417516

• How Medicaid Postpartum Coverage and PPD Screening Could Improve Diabetes and Blood Pressure Care After Birth

  A large NIH grant is studying how extending Medicaid after birth and mandating postpartum depression screening affect care for women with gestational diabetes and pregnancy-related high blood pressure.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11401158

• Virtual group care to prevent postpartum depression in immigrant Latinas

  A federally funded program tests a virtual group, based on CBT and attachment theory, to help pregnant women and new mothers from immigrant Latina communities reduce postpartum depression symptoms.

  NIH research Northwestern University · Chicago, United States · NIH-11397717

• Group-based prevention of postpartum depression delivered in person or online

  A one-stop program to help pregnant people avoid postpartum depression, tested whether virtual sessions work as well as in-person ones.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-11385910

• Environmental factors linked to maternal postpartum depression and child mental-emotional-behavioral disorders in urban California kids

  This project looks at how things like extreme heat, wildfire smoke, and pollutants may contribute to parental postpartum depression and mental-emotional-behavioral issues in children living in cities, with a focus on Southern California families.

  NIH research University of California-Irvine · Irvine, United States · NIH-11379562

• Understanding how oxytocin in pregnancy affects postpartum mood and anxiety

  This research looks at how natural and synthetic oxytocin around birth may influence a mother’s risk for postpartum depression and anxiety, with the goal of spotting biomarkers early.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11344749

• miRNA patterns in neuron-derived exosomes and postpartum depression

  This grant explores how tiny brain-derived messengers in the blood relate to postpartum depression in new mothers.

  NIH research University of Virginia · Charlottesville, United States · NIH-11304606

• Changes in brain reward systems during pregnancy and after childbirth

  This project tracks how the brain's reward and mood systems change during pregnancy and after birth to better understand who may develop postpartum depression.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11243511

• Mother–baby emotional and brain synchrony after birth

  This project looks at how mothers with postpartum depression and their infants share emotions and brain activity to learn what supports healthy emotional development.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11234244

• Postpartum depression risk in female veterans

  Researchers are creating a rat model that mimics the repeated stresses female veterans often face to learn how those stresses may lead to postpartum depression.

  NIH research Veterans Health Administration · Columbia, United States · NIH-11212783

• CBT smartphone app to help prevent postpartum depression

  This project provides a smartphone app that delivers group-based cognitive behavioral therapy to help prevent postpartum depression in new mothers, especially those facing barriers to in-person care.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11163404

• How extended Medicaid and required postpartum depression screening affect care after pregnancies with gestational diabetes or high blood pressure

  This project compares Louisiana (which extended Medicaid coverage and requires postpartum depression screening) to Mississippi to see if longer coverage and required screening improve blood sugar, blood pressure, and mood follow-up for people who had gestational diabetes or pregnancy-related high blood pressure.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11158777

• Group program to prevent postpartum depression, offered in-person or online

  This compares a group program given in person or by video to help pregnant people lower their chance of postpartum depression, offered in English and Spanish.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-11128331

• Scaling ROSE to prevent postpartum depression for all new mothers

  Seeing if offering the ROSE program to all pregnant people and new mothers helps prevent postpartum depression.

  NIH research Michigan State University · East Lansing, United States · NIH-11127736

• Using ketamine to help mothers with depression and pain after cesarean delivery

  This study is looking at how ketamine can help new moms feel better by reducing postpartum depression and pain after a cesarean delivery, and it aims to find the best dose to improve their mood and manage pain safely.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11086759

• Examining how neuron-derived exosomes relate to postpartum depression

  This study is looking at tiny particles from brain cells in the blood to see how they might be linked to postpartum depression, helping us understand what happens in the brain of new moms who are feeling down after childbirth.

  NIH research University of Virginia · Charlottesville, United States · NIH-11035438

• Preventing postpartum depression in sexual and gender minority pregnant people through in-person and virtual programs

  This study is looking at how well a special program called ROSE helps prevent postpartum depression in pregnant people from sexual and gender minority communities, and it compares whether in-person or online sessions work better for their mental health.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-11020219

• Using morning light therapy to treat postpartum depression

  This study is looking at how a special light device that you can wear in the morning might help new moms feel better if they're dealing with postpartum depression, making it easier for them to improve their mood without taking medication.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11001739

• Exploring how postpartum depression affects Black mothers and their infants' emotional development.

  This study looks at how postpartum depression affects Black mothers and their babies, exploring how a mother's feelings can impact her baby's emotional growth and responses, while also considering the challenges they face, like racial discrimination.

  NIH research State University of New York at Albany · Albany, United States · NIH-10997476

• Understanding how brain function affects postpartum depression risk

  This study is looking at how changes in brain activity related to motivation and reward might help us understand the risk of postpartum depression in new moms, so we can better support their mental health during and after pregnancy.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-10984981

• Exploring the connection between mother-infant interactions and postpartum depression

  This study looks at how the way mothers and their babies connect after birth affects the baby's emotional growth, especially when the mother is dealing with postpartum depression, and it hopes to find ways to help both moms and their little ones feel better together.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10954716

• Understanding postpartum depression in female veterans using an animal model

  This study is looking at postpartum depression in female veterans by using female rats to mimic the unique stresses they experience, helping researchers understand the causes of PPD in these women.

  NIH research Veterans Health Administration · Columbia, United States · NIH-10925044

• An app to help prevent postpartum depression in new mothers

  This study is testing a smartphone app that offers support and therapy for new moms who might be struggling with postpartum depression, especially those who may find it hard to get help in traditional ways, so they can feel better and have the support they need.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-10910932

• Effects of extended Medicaid coverage and postpartum depression screening on care for gestational diabetes and pregnancy-induced hypertension

  This study is looking at how extending Medicaid coverage after childbirth and requiring screenings for postpartum depression can help new moms in Louisiana get better care for issues like gestational diabetes and high blood pressure, and it will compare their experiences to those of moms in Mississippi, where these cha

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-10908675

• Exploring a program to prevent postpartum depression in new mothers

  This study is looking at a program called ROSE that helps all new moms by offering support and resources to prevent postpartum depression, so if you're a new mother, you can benefit from this program to help keep your mental health in check during this important time.

  NIH research Michigan State University · East Lansing, United States · NIH-10904847

• Preventing postpartum depression through in-person and virtual group programs

  This study is looking at how well a support program for new moms can help prevent postpartum depression, comparing in-person meetings at hospitals with online video sessions, and it's especially for pregnant women from diverse backgrounds who might need extra help.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-10874697

• Investigating brain chemistry changes in postpartum depression

  This study is looking at how certain brain chemicals are linked to postpartum depression in women, and it hopes to find clues that could help improve treatments for those feeling down after having a baby.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-10793623

• Using morning light therapy to treat postpartum depression

  This study is looking at how a special light therapy device that you can wear at home might help new moms with postpartum depression feel better without using medication.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10768566

• Understanding how brain circuits affect maternal sensitivity in postpartum depression

  This study looks at how certain brain areas affect how mothers care for their kids, especially when they're dealing with postpartum depression, to better understand what happens in the brain that changes their behavior.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-10726256

• Using prenatal yoga to help prevent postpartum depression

  This study is testing a virtual prenatal yoga program to see if it can help prevent postpartum depression in women at higher risk, especially those from diverse backgrounds, by promoting mindfulness and physical activity.

  NIH research Henry Ford Health System · Detroit, United States · NIH-10723544

• Mindfulness program for pregnant Black and Latina women at risk of postpartum depression

  This study is testing a convenient mindfulness program on a mobile app for pregnant Black and Latina women who might be at risk for postpartum depression, helping them feel better with just 10-20 minutes of practice each day for six weeks.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-10683084

• Understanding the causes and risks of postpartum depression

  This study is looking at postpartum depression, which many new moms experience, to understand its different types and the genetic factors involved, so we can create better ways to predict and treat it for healthier outcomes for both moms and their babies.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10652450

Related topics

Quick answers

How many Postpartum Depression clinical trials are recruiting right now?

28, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (14 trials), Italy (2 trials), Taiwan (2 trials), Spain (2 trials), Turkey (Türkiye) (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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