Mindfulness intervention for mothers and infants

Mother-infant Bonding in the Brain: Promoting Maternal Mental Health and High-quality Mother-infant Interactions Via a Mindfulness-based Intervention

Not applicable Interventional Tilburg University · NCT05830266

This study tests if a mindfulness program for mothers and their babies can help reduce postpartum depression and anxiety while strengthening their bond.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment64 (estimated)
Ages18 Years and up
SexFemale
SponsorTilburg University Academic / other
Locations1 site (Tilburg, North Brabant)
Trial IDNCT05830266 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of a mindfulness-based intervention called 'Mindful with your Baby' for women experiencing postpartum depression, anxiety, and parental stress. The intervention is designed for mothers with infants aged 5-9 months and aims to enhance the mother-infant bond while reducing mental health issues. Participants will engage in both group-based therapist-guided sessions and self-guided online activities. The study hypothesizes that this approach will improve behavioral interactions and neural synchrony between mothers and their infants.

Who should consider this trial

Good fit: Ideal candidates are Dutch-speaking women aged 18 and older who are experiencing postpartum depression, anxiety, or parental stress after having a baby between 5-9 months old.

Not a fit: Patients with severe psychiatric disorders, substance abuse issues, or those who do not have internet access may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the mental health of postpartum women and strengthen the bond with their infants.

How similar studies have performed: While mindfulness interventions have shown promise in other contexts, this specific approach focusing on mother-infant bonding is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pregnant women (18+y).
* First antenatal visit \< 12 weeks.
* Score above cut off on the Edinburgh Postnatal Depression Scale (EPDS), the anxiety subscale of the Symptom Checklist (SCL-90) and/or the Parental Stress Questionnaire (PSQ) at 8-10 weeks postpartum.
* Dutch-speaking or understanding Dutch.

Exclusion Criteria:

* Gemelli pregnancy (or higher order pregnancy).
* Known endocrine disorder before pregnancy (diabetes-I, Rheumatoid arthritis).
* Severe psychiatric disease (schizophrenia, borderline or bipolar disorder).
* HIV.
* Drug or alcohol addiction problems.
* Any other disease resulting in treatment with drugs that are potentially adverse for the fetus and need careful follow-up during pregnancy.
* No access to the internet.

Where this trial is running

Tilburg, North Brabant

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Postpartum DepressionPostpartum AnxietyParental StressPostpartum depressionPostpartum anxietyParental stressMindfulnessMindful with your baby
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.