Investigating brain chemistry changes in postpartum depression
Official title: Relationships between Neuroactive Steroids, GABA and Glutamate MRS and Connectivity of the Default Mode Network in Postpartum Depression
Funded at Feinstein Institute for Medical Research · NIH-10793623 · Data updated 2026-11-12
This study is looking at how certain brain chemicals are linked to postpartum depression in women, and it hopes to find clues that could help improve treatments for those feeling down after having a baby.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | May 4, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $481,011 |
| NIH project number | 5R01MH120313-05 |
| Project ID | NIH-10793623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postpartum women, particularly those experiencing symptoms of depression.
✕Less likely to help
Patients who are not postpartum or who do not have symptoms of depression may not receive any benefit from this research.
What this research studies
This research explores the connections between neuroactive steroids and brain chemicals in women experiencing postpartum depression. By comparing the brain activity and chemical levels of postpartum women with and without depression, the study aims to uncover the underlying mechanisms that contribute to this condition. Participants will undergo assessments that measure GABA and glutamate concentrations in the brain, as well as their connectivity patterns. The goal is to identify potential biomarkers that could lead to better treatment options for postpartum depression.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for postpartum depression, benefiting both mothers and their children.
How similar studies have gone: Previous research has shown promising results in understanding the role of neuroactive steroids in mood disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Deligiannidis, Kristina Marie — Feinstein Institute for Medical Research
- Study coordinator: Deligiannidis, Kristina Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.