Universal prevention of postpartum depression using the ROSE program
Official title: The ROSE Scale-up Study: Informing a Decision About ROSE as Universal Postpartum Depression Prevention
Run by Michigan State University · NCT05700760 · Data updated 2026-11-12
This study is testing whether a program called ROSE can help prevent postpartum depression in all pregnant women, not just those at risk, by making it easier to access during prenatal care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 2320 (estimated) |
| Sponsor | Michigan State University Academic / other |
| Locations | 1 site (Flint, Michigan) |
| Status | Recruiting |
| Started | June 1, 2023 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | May 18, 2026 |
| Trial ID | NCT05700760 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pregnant women aged 18 or older who are receiving prenatal services in the U.S. and are between 12-32 weeks pregnant.
✕Probably not a fit
Patients currently experiencing a major depressive episode or those with a diagnosis of bipolar or psychotic disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The ROSE Scale-up initiative aims to implement the Reach Out, Stand Strong, Essentials for New Mothers (ROSE) program, an evidence-based intervention designed to prevent postpartum depression (PPD) in pregnant women. This program has been shown to reduce PPD cases by approximately 50% and is scalable due to its flexible delivery methods and lack of requirement for licensed mental health professionals. The study will assess the feasibility of offering ROSE universally to all women receiving prenatal care, rather than just those identified as at risk, thereby streamlining the prevention process. The research will involve collaboration with various healthcare and community agencies to evaluate the implementation and sustainability of the program.
Why it matters
Potential benefit: If successful, this program could significantly reduce the incidence of postpartum depression among new mothers.
How similar studies have gone: Previous studies have demonstrated the effectiveness of the ROSE program in preventing postpartum depression, indicating a strong foundation for this universal approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Is aged 18 or older 2. Is receiving prenatal services within the U.S 3. Is between 12-32 weeks pregnant 4. Speaks and understand English well enough to understand questionnaires when they are read aloud 5. Has access to a telephone through owning one, a relative/friend, or an agency 6. Is willing and able to provide the name and contact information of at least two locator persons Exclusion Criteria: 1. Has a current major depressive episode 2. Has current or past diagnosis of a bipolar disorder or a psychotic disorder
Where it's running
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Michigan State University
Flint, Michigan, United States Recruiting
Study contacts
- Principal investigator: Jennifer E Johnson, PhD — Michigan State University
- Study coordinator: Jennifer E Johnson, PhD
- Email: jjohns@msu.edu
- Phone: 810-600-5669
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.