Universal prevention of postpartum depression using the ROSE program

The ROSE Scale-up Study: Informing a Decision About ROSE as Universal Postpartum Depression Prevention

Not applicable Interventional Michigan State University · NCT05700760

This study is testing whether a program called ROSE can help prevent postpartum depression in all pregnant women, not just those at risk, by making it easier to access during prenatal care.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment2320 (estimated)
Ages18 Years and up
SexFemale
SponsorMichigan State University Academic / other
Locations1 site (Flint, Michigan)
Trial IDNCT05700760 on ClinicalTrials.gov

What this trial studies

The ROSE Scale-up initiative aims to implement the Reach Out, Stand Strong, Essentials for New Mothers (ROSE) program, an evidence-based intervention designed to prevent postpartum depression (PPD) in pregnant women. This program has been shown to reduce PPD cases by approximately 50% and is scalable due to its flexible delivery methods and lack of requirement for licensed mental health professionals. The study will assess the feasibility of offering ROSE universally to all women receiving prenatal care, rather than just those identified as at risk, thereby streamlining the prevention process. The research will involve collaboration with various healthcare and community agencies to evaluate the implementation and sustainability of the program.

Who should consider this trial

Good fit: Ideal candidates for this study are pregnant women aged 18 or older who are receiving prenatal services in the U.S. and are between 12-32 weeks pregnant.

Not a fit: Patients currently experiencing a major depressive episode or those with a diagnosis of bipolar or psychotic disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly reduce the incidence of postpartum depression among new mothers.

How similar studies have performed: Previous studies have demonstrated the effectiveness of the ROSE program in preventing postpartum depression, indicating a strong foundation for this universal approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Is aged 18 or older
2. Is receiving prenatal services within the U.S
3. Is between 12-32 weeks pregnant
4. Speaks and understand English well enough to understand questionnaires when they are read aloud
5. Has access to a telephone through owning one, a relative/friend, or an agency
6. Is willing and able to provide the name and contact information of at least two locator persons

Exclusion Criteria:

1. Has a current major depressive episode
2. Has current or past diagnosis of a bipolar disorder or a psychotic disorder

Where this trial is running

Flint, Michigan

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Postpartum Depressionpostpartum depressionantenatal depressiondepressionpreventiondepression preventionpregnancy
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.