Comparing in-person and virtual group therapy to prevent postpartum depression

Group-based Prevention of Postpartum Depression: In-person vs. Virtual Delivery

Not applicable Interventional University of Denver · NCT05766475

This study is testing whether a group therapy program delivered online or in-person can help prevent postpartum depression in pregnant women, especially those from disadvantaged backgrounds.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment900 (estimated)
Ages18 Years and up
SexFemale
SponsorUniversity of Denver Academic / other
Locations1 site (Denver, Colorado)
Trial IDNCT05766475 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the effectiveness of a group interpersonal therapy program, known as ROSE, in preventing postpartum depression (PPD) when delivered virtually versus in-person. The study focuses on pregnant women, particularly from socioeconomically disadvantaged and minoritized backgrounds, to address significant health disparities. Participants will be randomly assigned to receive the ROSE program either in-person at their prenatal care hospital or virtually through video conferencing, with sessions available in both English and Spanish. The trial will involve 900 diverse pregnant individuals to assess the scalability and accessibility of the intervention.

Who should consider this trial

Good fit: Ideal candidates for this study are pregnant women who are less than 30 weeks gestational age and speak either English or Spanish.

Not a fit: Patients who are not pregnant or those who are beyond 30 weeks gestational age will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a scalable and accessible method for preventing postpartum depression among diverse populations.

How similar studies have performed: Other studies have shown success with similar virtual interventions for mental health, indicating potential for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* English or Spanish speaking
* Less than 30 gestational weeks

Exclusion Criteria:

* None

Where this trial is running

Denver, Colorado

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Postpartum DepressionPrenatal depressionhealth disparitiespreventative interventionvirtual therapyinterpersonal therapy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.