Scaling ROSE to prevent postpartum depression for all new mothers
Official title: The ROSE Scale-Up Study: Informing a decision about ROSE as universal postpartum depression prevention
Funded at Michigan State University · NIH-11127736 · Data updated 2026-11-12
Seeing if offering the ROSE program to all pregnant people and new mothers helps prevent postpartum depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,194,067 |
| NIH project number | 5R01MH130948-04 |
| Project ID | NIH-11127736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people and new mothers receiving care at participating clinics or community programs are the ideal candidates for participation.
✕Less likely to help
People already experiencing active major depression who need treatment rather than prevention, or those not served by participating sites, may not benefit from this prevention-focused program.
What this research studies
You may be offered ROSE — a short, evidence-based program — as part of routine prenatal or postpartum visits at participating clinics. The project partners with healthcare and community agencies to offer ROSE to every woman and uses electronic health records and enrollment data to follow who receives the program and their outcomes. Researchers will measure postpartum depression rates, costs, feasibility, and whether universal offering reduces disparities in care. The goal is to inform whether ROSE should be routinely offered to all new mothers.
Why it matters
Potential benefit: If successful, this could reduce the number of postpartum depression cases and make preventive support more widely available.
How similar studies have gone: Prior trials found ROSE prevents about half of postpartum depression cases among low-income, higher-risk women, but universal delivery to all women has not been well tested.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Johnson, Jennifer E — Michigan State University
- Study coordinator: Johnson, Jennifer E
Related research
Other NIH-funded projects on the same topics.
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Group-based postpartum depression prevention: in-person vs. virtual delivery
A large study is testing whether the ROSE group program delivered virtually to pregnant people is just as helpful as the in-person version in preventing postpartum depression.
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Postpartum depression screening at well-child visits in Arkansas
A study examines whether adding depression screening at baby visits in Arkansas improves detection and care for new mothers.
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Ketamine to reduce postpartum depression and pain after cesarean delivery
This grant explores a ketamine approach to help new mothers after cesarean delivery feel better sooner and with less pain.
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Trajectories of Positive Motivation and Postpartum Depression Risk
This project studies how brain reward function and daily mood patterns before and after birth relate to the risk of postpartum depression, with a focus on mothers and babies.
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ROSE Scale-Up: Expanding universal postpartum depression prevention for new mothers
A national effort to roll out the ROSE prevention program to all new mothers, to see if universal use can reduce postpartum depression.
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How Medicaid Postpartum Coverage and PPD Screening Could Improve Diabetes and Blood Pressure Care After Birth
A large NIH grant is studying how extending Medicaid after birth and mandating postpartum depression screening affect care for women with gestational diabetes and pregnancy-related high blood pressure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.