Exploring caregiver-infant relationships in the NICU

Study on the Developmental Value of the Physical and Vocal Contact Relationship Between Preterm Infant in the NICU and Caregivers (Mother, Father, Nurse)

Observational Istituto per la Ricerca e l'Innovazione Biomedica · NCT06462638

This study looks at how the voices of parents and nurses affect the development of preterm infants in the NICU and how parents' mental health may play a role in this relationship.

Quick facts

Study typeObservational
Enrollment80 (estimated)
Ages18 Years to 50 Years
SexAll
SponsorIstituto per la Ricerca e l'Innovazione Biomedica Academic / other
Locations1 site (Messina)
Trial IDNCT06462638 on ClinicalTrials.gov

What this trial studies

This observational study investigates the impact of caregiver contact relationships on the developmental processes of preterm infants. It focuses on how the neurobehavioral states of these infants respond to maternal and paternal voices compared to familiar non-parental voices, such as those of NICU nurses. Additionally, the study examines the psychological conditions of parents, particularly postpartum depression and anxiety, and how these factors may influence infant responses. The aim is to enhance understanding of the caregiver-infant dynamic in neonatal intensive care settings.

Who should consider this trial

Good fit: Ideal candidates include preterm infants aged 33 to 36 weeks and their parents aged 18 to 50 years.

Not a fit: Patients with congenital anomalies, neurological disorders, or parents with psychiatric disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve developmental outcomes for preterm infants by highlighting the importance of caregiver interactions.

How similar studies have performed: While the specific focus on paternal voice is less explored, similar studies have shown positive outcomes from caregiver interactions in neonatal settings.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* For infants: Infants with gestational age between 33 and 36 weeks, weighing around 2kg (LBW - low birth weight), in whom life-threatening conditions have been averted and in stable medical condition will be included in the study.
* For parents: Male and female adults aged between 18 and 50 years.

Exclusion Criteria:

* For infants: Presence of congenital anomalies, neurological disorders, genetic syndromes, and any other condition of developmental atypicality.
* For parents: Parents under 18 years of age; Parents with diagnosed psychiatric disorders and/or sensory disabilities; single parents.

Where this trial is running

Messina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Preterm BirthPostpartum Depressionpreterm birthcontact relationshippostpartum depression
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.