Condition

Perinatal Depression clinical trials and research

• 17Clinical trials
• 25NIH research projects
• 6Countries

Newest Perinatal Depression clinical trials

All recruiting trials (17)

• Two-Door Doulas: Enhanced vs Standard Medicaid Doula Care in Pregnancy

  This trial tests whether an enhanced, earlier, and more frequent doula support program helps pregnant people on Medicaid feel less depression and anxiety after birth compared with the standard Medicaid doula care in Florida.

  Recruiting University of Florida · Gainesville, Florida · NCT07799805

• Personalized mobile health support to prevent maternal depression and anxiety during pregnancy

  A personalized mobile health program added to ordinary care is tested to see if it can prevent depression and anxiety in pregnant people and support partners.

  Recruiting University of Seville · Mairena del Aljarafe, Sevilla · NCT07613008

• Early referral in perinatal mental health approach

  We’re testing a mobile program in routine maternal care to see if early detection and referral for depression and anxiety in pregnant and recently postnatal women is feasible and acceptable, and whether an AI screening tool can help identify those at risk.

  Recruiting University of Seville · Mairena del Aljarafe, Sevilla · NCT07609550

• Parents and Babies: a virtual and hybrid program to support perinatal mood for LGBTQ+ parents

  A pilot program tests a Parents and Babies intervention to see if it’s feasible, acceptable, and potentially helpful for LGBTQ+ people who are pregnant or within a year postpartum and have mild depressive symptoms.

  Recruiting Northwestern University · Chicago, Illinois · NCT07607613

• Virtual forest mindfulness for pregnant women

  A randomized trial tests whether a VR forest mindfulness program helps improve mental health for pregnant women around 20–24 weeks of gestation, compared with standard mindfulness training.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT07606248

• Health and Response: Digital Markers for Outcomes in Perinatal Depression Treatment

  This study tests whether data from phones and wearables collected early in perinatal depression treatment can better predict outcomes when added to self-reported symptoms.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07577947

• Reaching Calm: A digital program to help prevent anxiety during pregnancy

  A digital program called Reaching Calm is tested in obstetric clinics to see if it can help prevent anxiety for pregnant people at risk.

  Recruiting University of Massachusetts, Worcester · Leominster, Massachusetts · NCT07458698

• Doula Link: training doulas to support perinatal mental health

  This test will see if training doulas with the Doula Link program helps pregnant and postpartum people with depression or anxiety.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT07217561

• Accelerated TMS for perinatal and postpartum depression

  This project will test whether an accelerated course of TMS (multiple sessions per day over five days) can help pregnant and postpartum people with major depressive disorder.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06968390

• Pathways to equitable perinatal mental health care

  This project will test whether a healthcare-only approach or a healthcare-community partnership helps pregnant and postpartum people get better care for depression and anxiety.

  Recruiting University of Massachusetts, Worcester · Shrewsbury, Massachusetts · NCT06790641

• TrueBlue mobile app for tracking depression and anxiety during pregnancy and after birth

  This project will test whether the TrueBlue smartphone app can monitor symptoms of depression, anxiety, and loss of pleasure in people who are pregnant or within 12 weeks after giving birth.

  Recruiting BlueSkeye AI · Nottingham, Nottinghamshire and 1 other locations · NCT06364488

• Exploring how maternal depression affects infant feeding in new mothers

  This study looks at how depression in new mothers affects how they feed their babies, including breastfeeding and introducing solid foods.

  Recruiting National Taiwan University Hospital · Taipei · NCT06231602

• Exploring the link between maternal gut microbiome and perinatal depression and anxiety

  This study is testing if improving gut health with diet and supplements can help pregnant women who have a history of depression and anxiety feel better during and after pregnancy.

  Recruiting Phase 2/3 The Canadian College of Naturopathic Medicine · Toronto, Ontario · NCT06074250

• Improving access to mental health support for pregnant and postpartum women

  This study is testing a new online mental health support program for pregnant and new moms who might be at risk for postpartum depression to see how well it works for different people.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06049433

• Mobile app for managing anxiety and depression in pregnant and postpartum individuals

  This study is testing a mobile app that helps pregnant and new parents manage anxiety and depression to see if it can provide useful support during this time.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05897619

• Health-education program for gestational diabetes and perinatal depression

  This program will try short health-education clips and questionnaires to see if improving health behaviors reduces depressive symptoms in pregnant people with gestational diabetes.

  Recruiting National Taiwan University Hospital · Taipei · NCT05800509

• Improving maternal and child health by addressing perinatal depression

  This study is testing a new online support program for pregnant women with depression to see if it can improve their health and the health of their babies during the first 1000 days of life.

  Recruiting University of Helsinki · Helsinki, Uusimaa · NCT04069091

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Couples-based approach to prevent perinatal depression in rural India

  A new, family-focused program helps new mothers and their husbands address perinatal depression in rural India using trained lay counselors.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11539072

• Couples-based approach to prevent perinatal depression in rural India

  A pilot program in rural India tests a couples-based, lay-counselor–delivered approach to prevent perinatal depression for new mothers and their partners.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11538905

• Machine learning to tailor and prevent perinatal depression for pregnant and new mothers

  A machine learning project at Carnegie Mellon aims to find personalized, scalable ways to prevent perinatal depression in pregnant people and new mothers.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11415592

• Online sleep therapy to prevent depression during and after pregnancy

  This project will see whether an online cognitive behavioral therapy for insomnia can help prevent depression during pregnancy and in the first year after childbirth for pregnant people with insomnia.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11402619

• Understanding how gut and body signals interact to influence perinatal depression

  A study of pregnant people exploring how the gut microbiome and body signals contribute to depression during and after pregnancy.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11372334

• Couples program to prevent depression during pregnancy and after birth in rural India

  A couples-based program to help first-time pregnant women and their partners in rural India lower the chance of depression during pregnancy and after childbirth.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11371935

• IMAGINE digital group program to prevent perinatal depression

  This pilot offers a mobile group-based cognitive behavioral program called IMAGINE to help pregnant and postpartum people lower their chance of developing depression.

  NIH research University of Washington · Seattle, United States · NIH-11289432

• Understanding the link between mothers' bodies, gut microbes, and depression during and after pregnancy

  This project explores how the balance between a mother's body and her gut bacteria might contribute to depression during and after pregnancy, especially for Black and Latina women.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11193517

• Understanding how gestational diabetes and depression during pregnancy affect mothers and their children

  This project explores how gestational diabetes and depression during pregnancy might influence a mother's mental health after birth and her child's brain development.

  NIH research New York University School of Medicine · New York, United States · NIH-11178601

• Personalized prevention for perinatal depression using machine learning

  Using machine learning, this project will match pregnant people and new parents with the right preventive mental-health support before depression starts.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11175529

• Helping couples in rural India prevent depression during pregnancy and after birth

  This project helps first-time pregnant couples in rural India learn ways to support each other and prevent depression during pregnancy and after childbirth.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11159564

• Coordinated support for depression during and after pregnancy

  A collaborative care approach to help pregnant and postpartum people get better screening, treatment, and follow-up for depression.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11121079

• Using machine learning to create personalized prevention strategies for perinatal depression

  This study is looking to use smart technology to create personalized support for people dealing with perinatal depression, helping to figure out who might need specific help the most, so they can get the best care during pregnancy and after.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11060670

• A digital program to help prevent depression during and after pregnancy

  This study is testing a friendly online program called IMAGINE that helps pregnant people and new parents prevent depression by using helpful techniques on their phones, making it easier for them to get support when they need it.

  NIH research University of Washington · Seattle, United States · NIH-11031424

• The effects of gestational diabetes and maternal depression on child development

  This study looks at how having gestational diabetes and feeling depressed during pregnancy might affect how children develop, and it’s for moms-to-be who want to understand how their health can impact their little ones.

  NIH research New York University School of Medicine · New York, United States · NIH-11010561

• Improving support for women with depression during and after pregnancy

  This study is working to improve support for women dealing with depression during and after pregnancy by bringing together mental health and pregnancy care, making sure everyone gets the help they need, no matter their background.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-10931689

• Understanding perinatal depression in sexual and gender minorities

  This study is all about helping LGBTQ+ parents who might be feeling down during pregnancy or after having a baby, and it aims to create support programs that really fit their needs to improve their mental health.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10931665

• Preventing depression in new parents with a history of childhood trauma

  This study is looking at how to help expectant parents who have faced tough times in their childhood by providing extra mental health support during their pregnancy, especially in the last few months, to ensure both they and their baby stay healthy and happy.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10929508

• Improving support for mothers with depression to enhance HIV prevention in Malawi

  This study is looking at how involving partners can help mothers with perinatal depression stick to their HIV prevention plans, making it easier for them to communicate and support each other while getting the care they need in Zomba, Malawi.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10924679

• How gestational diabetes and depression affect mothers and their children's brain development

  This study is looking at how gestational diabetes and prenatal depression can affect a mom's mental health and the brain development of her baby, with the goal of finding ways to better support moms and their little ones.

  NIH research New York University School of Medicine · New York, United States · NIH-10922858

• Creating a text messaging program to help prevent depression in pregnant individuals

  This study is testing a helpful text messaging program designed to support pregnant people and new parents dealing with depression, making it easier for them to get the care and encouragement they need right on their phones.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-10874712

• Preventing perinatal depression in couples in rural India

  This study is looking to help first-time pregnant couples in rural central India by testing a program that strengthens their relationship and support for each other to prevent depression during and after pregnancy.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10864570

• Preventing perinatal depression using a web-based program.

  This study is looking at how to use a helpful online tool called YoMingo® to support expectant and new parents, especially in Latino and underserved communities, to prevent perinatal depression and make sure it fits well with their healthcare.

  NIH research University of Utah · Salt Lake City, United States · NIH-10638338

• Improving treatment for depression in new mothers and their infants

  This study is looking at a new way to help women who are feeling depressed during and after pregnancy by improving their connection with their babies and boosting their confidence as parents, and it will compare this new approach to regular care to see which works better.

  NIH research University of Washington · Seattle, United States · NIH-10557092

• Improving treatment for depression in pregnant women using light and sleep therapies

  This study is exploring a new way to help expectant mothers dealing with perinatal depression and anxiety by using bright light therapy and sleep management, and it’s looking for participants to see if this approach works better than standard care.

  NIH research Rhode Island Hospital · Providence, United States · NIH-10523528

Related topics

Quick answers

How many Perinatal Depression clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), Taiwan (3 trials), Spain (2 trials), Canada (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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