Examining how neuron-derived exosomes relate to postpartum depression
Official title: miRNA Expression Patterns of Neuron Originating Exosomes and Postpartum Depression
Funded at University of Virginia · NIH-11035438 · Data updated 2026-11-12
This study is looking at tiny particles from brain cells in the blood to see how they might be linked to postpartum depression, helping us understand what happens in the brain of new moms who are feeling down after childbirth.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | March 17, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $246,306 |
| NIH project number | 1R21MH138836-01 |
| Project ID | NIH-11035438 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include new mothers experiencing symptoms of postpartum depression.
✕Less likely to help
Patients who are not new mothers or who do not experience postpartum depression may not benefit from this research.
What this research studies
This research investigates the role of neuron-derived exosomes in postpartum depression (PPD) by analyzing their microRNA expression patterns. The study focuses on understanding the neurobiological mechanisms behind PPD, which affects many new mothers and can impair their ability to care for their newborns. By examining these exosomes found in blood serum, the research aims to uncover insights into how they may reflect brain health and contribute to PPD. This approach leverages the ability of these exosomes to cross the blood-brain barrier, potentially revealing important information about central nervous system processes related to PPD.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for diagnosing and treating postpartum depression.
How similar studies have gone: Previous research has shown promise in using neuron-derived exosomes to understand various neurological conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Payne, Jennifer L — University of Virginia
- Study coordinator: Payne, Jennifer L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.