Improving detection of metastatic osteosarcoma during surgery
Official title: Intraoperative Molecular Imaging of Metastatic Osteosarcoma with 111In-dinutuximab-IR800
Funded at University of Pittsburgh at Pittsburgh · NIH-11031944 · Data updated 2026-11-12
This study is testing a new way to help surgeons find and remove hard-to-see cancer spots in kids and teens with metastatic osteosarcoma by using special imaging tools during surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $85,444 |
| NIH project number | 5F32CA287961-02 |
| Project ID | NIH-11031944 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with metastatic osteosarcoma.
✕Less likely to help
Patients with localized osteosarcoma or other types of cancer not related to osteosarcoma may not benefit from this research.
What this research studies
This research focuses on enhancing the surgical removal of metastatic osteosarcoma by using intraoperative molecular imaging (IMI). It employs targeted radioisotopes and near-infrared fluorophores to help surgeons accurately identify cancerous tissues and differentiate them from normal tissues during surgery. By combining these technologies, the study aims to improve the detection of metastatic lesions that are often difficult to locate, particularly in the lungs, thereby potentially increasing the chances of complete tumor resection. This approach is especially crucial for children and adolescents suffering from this aggressive form of bone cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective surgical outcomes for patients with metastatic osteosarcoma, potentially improving survival rates.
How similar studies have gone: Previous studies have shown promise in using fluorescent agents for tumor resection, but this approach combining radioisotopes and fluorophores is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Rosenblum, Lauren Taylor — University of Pittsburgh at Pittsburgh
- Study coordinator: Rosenblum, Lauren Taylor
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.