Creating 3D models of osteosarcoma to improve drug discovery
Official title: Engineering 3D Osteosarcoma Models to Elucidate Biology and Inform Drug Discovery
Funded at Stanford University · NIH-11057512 · Data updated 2026-11-12
This study is creating special 3D models of osteosarcoma, a type of bone cancer that mainly affects kids and young adults, to help us learn more about how the cancer works and find better treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $643,432 |
| NIH project number | 5R01CA276872-03 |
| Project ID | NIH-11057512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with osteosarcoma.
✕Less likely to help
Patients with osteosarcoma who are already receiving treatment that is effective for their condition may not benefit from this research.
What this research studies
This research focuses on developing advanced 3D models of osteosarcoma, a type of bone cancer that primarily affects children and young adults. By using these models, the research aims to better understand the complex biology of osteosarcoma and how it responds to various treatments. The approach involves integrating tissue engineering techniques with high-dimensional genomic sequencing to explore the genetic diversity of the cancer and identify effective drug combinations. This innovative methodology seeks to overcome the limitations of traditional 2D cell cultures and animal models, providing a more accurate representation of tumor behavior in the human body.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for osteosarcoma patients, potentially improving survival rates and reducing drug resistance.
How similar studies have gone: Previous research has shown promise in using 3D cancer models for other types of tumors, indicating potential success for this novel approach in osteosarcoma.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Yang, Fan — Stanford University
- Study coordinator: Yang, Fan
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.