Home › Trials › NCT04132895

Improving outcomes for patients with osteosarcoma

ICONIC: Improving Outcomes Through Collaboration in OsteosarComa

Observational University College, London · NCT04132895

This study is trying to gather information and samples from people with osteosarcoma to better understand the disease and find ways to improve treatment and outcomes.

Quick facts

Study typeObservational
Enrollment300 (estimated)
SexAll
SponsorUniversity College, London Academic / other
Drugs / interventionschemotherapy
Locations22 sites (London, Greater London and 21 other locations)
Trial IDNCT04132895 on ClinicalTrials.gov

What this trial studies

This project aims to collect high-quality clinical data and biological samples from patients diagnosed with osteosarcoma, a common bone cancer. By gathering information on disease characteristics, treatment responses, and patient demographics, the study seeks to enhance understanding of osteosarcoma biology. The collected blood and tissue samples will be analyzed in research laboratories to identify potential tumor markers and improve treatment strategies. The ultimate goal is to improve patient outcomes through better-informed clinical decisions.

Who should consider this trial

Good fit: Ideal candidates include patients of all ages with a new histological diagnosis of osteosarcoma or those with supportive imaging findings.

Not a fit: Patients diagnosed with osteosarcoma more than four months prior to registration may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies and outcomes for patients with osteosarcoma.

How similar studies have performed: While there have been few recent trials for osteosarcoma, this study's approach of comprehensive data collection and analysis is novel and aims to fill existing knowledge gaps.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* New histological diagnosis of osteosarcoma or in the absence of osteoid seen on biopsy, pathology and imaging supportive of a diagnosis of osteosarcoma. (It is well recognised that some patients may present with features suggestive of osteosarcoma (under 40 years, radiological abnormality compatible) but in whom no osteoid is detected in needle biopsy. Although categorised as spindle cell tumour of bone, such patients are usually treated in an identical approach to osteosarcoma. A definite diagnosis of osteosarcoma is then often possible after surgery when the entire resection specimen is available.)
* Written informed consent of patient and/or parent/legal guardian.

Exclusion Criteria:

• Diagnosis more than four months prior to registration.

Where this trial is running

London, Greater London and 21 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions OsteosarcomaBiobankGenomicsTumour markersImmuneOncology
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.