Condition

Wilms Tumor clinical trials and research

• 15Clinical trials
• 3NIH research projects
• 3Countries

Newest Wilms Tumor clinical trials

All recruiting trials (15)

• Becotatug Vedotin for EGFR-positive relapsed, refractory, or metastatic pediatric solid tumors

  This trial will test Becotatug Vedotin, an EGFR-targeted antibody-drug conjugate, to see if it is safe and helps children aged 2–18 with EGFR-positive relapsed, refractory, or metastatic solid tumors.

  Recruiting Phase 1 Sun Yat-sen University · Guangzhou, Guangdong · NCT07584499

• Personalized B7-H3 CAR T cells combined with PRAME antigen-specific T cells for relapsed embryonal tumors

  This trial tests a combined personalized B7-H3 CAR T cell and PRAME-specific T cell infusion after lymphodepleting chemotherapy in children and young adults with relapsed or refractory embryonal tumors.

  Recruiting Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT07172958

• GPC3-targeted CAR T cells armored with IL-15 and IL-21 for pediatric non‑CNS solid tumors

  This treatment will try personalized CAR T cells that target GPC3 and are engineered to make IL‑15 and IL‑21 in children and young adults with relapsed or refractory non‑CNS solid tumors that express GPC3.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT07148050

• Alpha/beta T‑Cell and B‑Cell Depletion plus Zoledronic Acid for Pediatric and Young Adult Solid Tumors

  This study will try removing alpha/beta T cells and B cells from donor stem cell grafts and giving zoledronic acid to see if it helps children and young adults (6 months to 25 years) with relapsed or high‑risk solid tumors tolerate allogeneic transplant and reduce relapse.

  Recruiting Phase 1/2 University of Florida · Gainesville, Florida · NCT06625190

• IL-15 and IL-21–armored GPC3-CAR T cell therapy for adults with GPC3-positive solid tumors

  This trial tests whether CAR T cells engineered to target GPC3 and fortified with IL-15 and IL-21 can treat adults with GPC3-positive liver and other solid tumors.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06198296

• Testing selinexor for treating Wilms tumors and other solid tumors

  This study is testing if selinexor can help children with certain hard-to-treat tumors, like Wilms tumors, feel better and improve their health.

  Recruiting at 16 sites Phase 2 Memorial Sloan Kettering Cancer Center · Los Angeles, California and 15 other locations · NCT05985161

• Metronomic chemotherapy for relapsed Wilms tumor

  This study is testing a new low-dose chemotherapy treatment for kids with relapsed Wilms tumor to see if it helps control their disease better than previous treatments.

  Recruiting at 15 sites Phase 1/2 Centre Oscar Lambret · Amiens and 17 other locations · NCT05384821

• Proton beam radiation for treating Wilms tumor in children

  This study tests if proton beam radiation can safely treat Wilms tumor in children while protecting healthy tissues better than regular radiation.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04968990

• B7-H3 CAR T-cell therapy for pediatric solid tumors

  This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04897321

• Tegavivint treatment for recurrent or refractory solid tumors in children

  This study tests if a new intravenous medication called tegavivint can help children with tough-to-treat solid tumors, like Ewing sarcoma and desmoid tumors, by finding the right dose and seeing how well it works.

  Recruiting at 19 sites Phase 1/2 Children's Oncology Group · Birmingham, Alabama and 20 other locations · NCT04851119

• Using engineered T cells to treat pediatric solid tumors

  This study is testing a new treatment using specially modified immune cells to see if they can help children with certain types of solid tumors, like liver cancer and rhabdomyosarcoma, feel better.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04715191

• Trastuzumab Deruxtecan for Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

  This study tests trastuzumab deruxtecan in children and young adults whose osteosarcoma, Wilms tumor, or desmoplastic small round cell tumor has come back or resisted treatment to see if the drug can help shrink tumors.

  Recruiting at 21 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 31 other locations · NCT04616560

• Combining vorinostat with chemotherapy for relapsed solid tumors and CNS cancers

  This study is testing if adding a drug called vorinostat to chemotherapy can help people with relapsed solid tumors and brain cancers feel better and improve their treatment outcomes.

  Recruiting Phase 1 New York Medical College · Valhalla, New York · NCT04308330

• Proton therapy for children with renal tumors

  This study is testing a new type of proton therapy for children with kidney tumors to see if it can reduce side effects from treatment while still being effective.

  Recruiting Early Phase 1 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT03810651

• Registry for rare lung tumors and DICER1-related conditions

  This study is collecting information about rare lung tumors in children, like pleuropulmonary blastoma, to help doctors understand how these conditions develop and how to treat them better.

  Recruiting Children's Hospitals and Clinics of Minnesota · Minneapolis, Minnesota · NCT03382158

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Fasting-mimicking diet and cancer stem cells in Wilms tumor

  Aiming to see if a fasting-mimicking diet can boost cancer-killing treatment while protecting healthy cells in children with Wilms tumor.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11434150

• Investigating the role of WT1 in a specific type of kidney cancer in children

  This study is looking at how certain gene changes in kids with Wilms tumor, a type of kidney cancer, might affect how the cancer grows and responds to treatment, with the goal of finding better ways to help those who are at higher risk.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11003706

• Investigating how mutations in a specific gene affect kidney development

  This study is looking at how changes in a specific gene called Wt1 affect the way kidney cells work together during development, which could help us understand kidney formation and problems that might arise, and it's designed for researchers who want to learn more about this process.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10841677

Related topics

Quick answers

How many Wilms Tumor clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (13 trials), France (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 7, Phase 2: 3, Phase 1/2: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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