Understanding how specific genes contribute to the development of bone cancer in children
Official title: Probing the mechanisms of dependency underlying skeletal genetic pathways of p53 and Notch in the pathogenesis of osteosarcoma
Funded at Sanford Research/usd · NIH-11108960 · Data updated 2026-11-12
This study is looking at how certain genes, especially p53 and Rb, affect the growth of osteosarcoma, a serious bone cancer that mainly affects kids, to help find better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $514,405 |
| NIH project number | 1R01CA300681-01 |
| Project ID | NIH-11108960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with osteosarcoma or those at high risk due to genetic predispositions.
✕Less likely to help
Patients with osteosarcoma who are already receiving treatment that does not involve genetic pathway exploration may not benefit from this research.
What this research studies
This research investigates the genetic pathways involved in the development of osteosarcoma, a severe bone cancer primarily affecting children. By studying genetically engineered mouse models that mimic human osteosarcoma, the researchers aim to uncover how certain genes influence the growth and spread of this cancer. The goal is to identify critical cancer-dependent pathways that could lead to the development of new and effective therapies for patients. This research is particularly focused on understanding the roles of the p53 and Rb genes in osteosarcoma progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve outcomes for children diagnosed with osteosarcoma.
How similar studies have gone: Previous research has shown promising results in understanding cancer pathways in other types of tumors, suggesting potential for success in this novel approach.
Where this research is happening
-
Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Tao, Jianning — Sanford Research/usd
- Study coordinator: Tao, Jianning
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.