Understanding how osteosarcoma spreads to the lungs
Official title: Epigenetic drivers of lung metastasis in osteosarcoma
Funded at Case Western Reserve University · NIH-10995632 · Data updated 2026-11-12
This study is looking at how bone cancer, called osteosarcoma, spreads to the lungs, and it aims to find new ways to stop this from happening, which could help patients get better treatments for their cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F30CA294663-01 |
| Project ID | NIH-10995632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults diagnosed with osteosarcoma, particularly those experiencing or at risk for lung metastasis.
✕Less likely to help
Patients with osteosarcoma who do not have lung metastasis or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates the mechanisms behind lung metastasis in osteosarcoma, a type of bone cancer that often spreads to the lungs. The study focuses on specific transcription factors and epigenetic changes that enable cancer cells to migrate and establish themselves in the lung tissue. By analyzing these factors, the researchers aim to identify potential targets for new therapies that could prevent or treat metastatic disease. Patients may benefit from insights that lead to more effective treatments tailored to their specific cancer subtype.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that significantly improve survival rates for patients with metastatic osteosarcoma.
How similar studies have gone: Previous research has shown promise in understanding the genetic and epigenetic factors involved in cancer metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Chin, Diana — Case Western Reserve University
- Study coordinator: Chin, Diana
Related research
Other NIH-funded projects on the same topics.
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Focal Adhesion Kinase inhibitor to block osteosarcoma spread to the lungs
A cancer treatment plan tests whether blocking a specific cell signal can stop osteosarcoma from growing and spreading to the lungs in kids and young people.
-
Epigenetic subtypes of osteosarcoma linked to chemo resistance and spread
This project looks for different molecular subtypes of osteosarcoma in children and young adults to understand why some tumors resist chemotherapy or spread.
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Understanding the genetic differences in osteosarcoma to improve treatment options
This study is looking at different types of osteosarcoma, a bone cancer that mostly affects kids and young adults, to find out how their genes work and how they might respond to treatments, so we can create better, more personalized therapies for patients.
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Stopping Osteosarcoma from Spreading
This project looks for new ways to stop osteosarcoma, a type of bone cancer common in young people, from spreading to other parts of the body.
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Targeting a protein to stop the spread of bone cancer in young people
This study is exploring how a protein called DKK-1 affects the spread of osteosarcoma, a type of bone cancer that often affects teens and young adults, and aims to find a new treatment that could help stop the cancer from spreading, inviting patients to join in by sharing their blood or tumor samples.
-
Lymph node metastasis and immune tolerance in head and neck cancer
A study in people with head and neck cancer looks at how cancer spread to lymph nodes may shape the immune system and help tumors grow.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.