Stopping Osteosarcoma from Spreading
Targeting DKK-1 To Prevent Osteosarcoma Metastasis
This project looks for new ways to stop osteosarcoma, a type of bone cancer common in young people, from spreading to other parts of the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11127707 on NIH RePORTER |
What this research studies
Osteosarcoma is a bone cancer that often affects teenagers and young adults. While surgery and chemotherapy can help many with localized disease, it's much harder to treat when the cancer has spread. This project explores a new approach by focusing on a protein called DKK-1, which seems to help osteosarcoma cells spread. Researchers believe that by blocking DKK-1, they can encourage cancer cells to mature and stop them from moving to other areas. This could lead to better outcomes for patients with this aggressive cancer.
Who could benefit from this research
Good fit: This research is focused on understanding and treating osteosarcoma, particularly in adolescents and young adults.
Not a fit: Patients without osteosarcoma or those whose cancer has already spread extensively may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent osteosarcoma from spreading, significantly improving survival rates for patients.
How similar studies have performed: Previous laboratory work has shown promising results in animal models where blocking DKK-1 prevented metastasis.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Loeb, David M. — Albert Einstein College of Medicine
- Study coordinator: Loeb, David M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.