Understanding how certain tumor cells survive and promote growth in osteosarcoma metastasis
Targeting cooperative mechanisms of metastatic colonization in osteosarcoma
This study is looking at how certain tumor cells in osteosarcoma change when they reach the lungs, which helps them survive and grow, and it aims to find out if chemotherapy might be leaving these cells unharmed, potentially leading to more cancer later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10916186 on NIH RePORTER |
What this research studies
This research investigates how specific tumor cells in osteosarcoma adapt to the lung environment, which is crucial for their survival and growth. The study focuses on a small group of tumor cells, referred to as 'anchor' cells, that stop dividing and release inflammatory signals, altering the lung tissue to support the growth of other tumor cells. By examining these mechanisms, the research aims to determine if chemotherapy treatments inadvertently leave these anchor cells unharmed, allowing them to contribute to future metastases. The project is structured into three main aims to rigorously test these hypotheses.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with osteosarcoma, particularly those experiencing metastasis to the lungs.
Not a fit: Patients with osteosarcoma that has not metastasized or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for osteosarcoma by targeting the mechanisms that allow tumor cells to survive and proliferate in the lungs.
How similar studies have performed: Previous research has shown promising results in understanding tumor cell behavior in metastatic environments, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Roberts, Ryan D. — Research Inst Nationwide Children's Hosp
- Study coordinator: Roberts, Ryan D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.