Condition

Synovial Sarcoma clinical trials and research

• 13Clinical trials
• 6NIH research projects
• 6Countries

Newest Synovial Sarcoma clinical trials

All recruiting trials (13)

• N-803 for progressive synovial sarcoma and myxoid/round cell liposarcoma after TCR-T therapy

  This trial tests whether N-803 can safely boost lingering TCR-T immune cells and help people whose synovial sarcoma or myxoid/round cell liposarcoma has progressed after prior TCR-T treatment.

  Recruiting Early Phase 1 Northwestern University · Chicago, Illinois · NCT07261657

• ACTengine IMA203 plus mRNA-4203 for cutaneous melanoma and synovial sarcoma

  This trial tests whether giving the ACTengine IMA203 T‑cell therapy together with the mRNA‑4203 vaccine is safe and helps people with HLA‑A*02:01 unresectable or metastatic cutaneous melanoma or synovial sarcoma who have had prior treatment.

  Recruiting at 4 sites Phase 1 Immatics US, Inc. · San Francisco, California and 3 other locations · NCT06946225

• Alpha/beta T‑Cell and B‑Cell Depletion plus Zoledronic Acid for Pediatric and Young Adult Solid Tumors

  This study will try removing alpha/beta T cells and B cells from donor stem cell grafts and giving zoledronic acid to see if it helps children and young adults (6 months to 25 years) with relapsed or high‑risk solid tumors tolerate allogeneic transplant and reduce relapse.

  Recruiting Phase 1/2 University of Florida · Gainesville, Florida · NCT06625190

• Using pasireotide to treat advanced synovial sarcoma and desmoplastic small round cell tumor

  This study is testing if the drug pasireotide can help young people with advanced synovial sarcoma and desmoplastic small round cell tumors stay healthy longer after their initial treatments.

  Recruiting Phase 2 University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg and 3 other locations · NCT06456359

• MASCT-I plus doxorubicin and ifosfamide as first-line treatment for advanced soft tissue sarcoma

  This trial will test whether adding MASCT-I to standard chemotherapy (doxorubicin and ifosfamide) helps adults with advanced soft tissue sarcoma respond better or live longer.

  Recruiting Phase 2 HRYZ Biotech Co. · Guangzhou · NCT06277154

• Evaluating treatments for non-rhabdomyosarcoma soft tissue sarcoma in young patients

  This study is testing a combination of chemotherapy and radiation to see if it helps young patients with non-rhabdomyosarcoma soft tissue sarcoma live longer without their cancer coming back.

  Recruiting at 7 sites Phase 1/2 St. Jude Children's Research Hospital · Atlanta, Georgia and 6 other locations · NCT06239272

• Personalized cancer vaccine for patients with fusion-driven sarcomas

  This study is testing a personalized cancer vaccine for patients with certain types of sarcomas to see if it can help their immune system fight the cancer and improve their chances of living longer.

  Recruiting Phase 1/2 University Hospital Tuebingen · Essen and 3 other locations · NCT06094101

• Using enhanced NK cells to treat advanced synovial sarcoma and myxoid/round cell liposarcoma

  This study is testing whether special immune cells can help people with advanced synovial sarcoma and myxoid/round cell liposarcoma feel better when used with chemotherapy.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT06083883

• Registry and biospecimen collection for synovial sarcoma patients

  This study is collecting medical information and samples from people with synovial sarcoma to help researchers find better treatments and improve care for future patients.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05910307

• Investigating afamitresgene autoleucel for pediatric cancers

  This study is testing a new treatment called afamitresgene autoleucel to see if it can help children and young adults with certain advanced cancers that have specific genetic markers.

  Recruiting at 10 sites Phase 1/2 USWM, LLC (dba US WorldMeds) · Palo Alto, California and 9 other locations · NCT05642455

• Exploring a new cancer treatment using PeptiCRAd-1 and checkpoint inhibitors

  This study is testing a new cancer treatment that combines a special virus with immune therapy to see if it can help people with advanced cancer who haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 Valo Therapeutics Oy · Frankfurt and 6 other locations · NCT05492682

• Using HER2 CAR T cells with checkpoint inhibitors for advanced sarcoma

  This study is testing a new treatment that combines personalized CAR T cells with immune boosters to see if it helps people with advanced HER2-positive sarcoma.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04995003

• Phase 3 test of anlotinib (AL3818) versus dacarbazine in advanced alveolar soft part sarcoma, leiomyosarcoma, and synovial sarcoma

  This trial tests whether anlotinib (AL3818) helps adults with advanced alveolar soft part sarcoma, while earlier arms compared anlotinib to dacarbazine for leiomyosarcoma and synovial sarcoma that are no longer enrolling.

  Recruiting Phase 3 Advenchen Laboratories, LLC · Phoenix, Arizona and 23 other locations · NCT03016819

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targetable Epigenetic and Immuno-Oncologic Vulnerabilities in Synovial Sarcoma

  A cancer research project at Sloan Kettering aims to find epigenetic and immune vulnerabilities in synovial sarcoma to guide future treatments.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11419133

• Sensor-based test for synovial sarcoma that detects SS18-SSX fusion mRNA and protein

  A patient-friendly test is being developed to rapidly and precisely detect the SS18-SSX cancer hallmark in synovial sarcoma using a new nanopore sensing method.

  NIH research University of California Santa Cruz · Santa Cruz, United States · NIH-11327757

• Finding drug and immune therapy targets for synovial sarcoma

  This project looks for weaknesses in synovial sarcoma cells that new drugs or immune therapies could target for people with synovial sarcoma.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11181599

• Targeting a specific pathway to treat synovial sarcoma

  This work explores a new way to stop synovial sarcoma, a type of cancer, by disrupting a process called SUMOylation.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11158588

• Disruption of a specific protein modification to treat synovial sarcoma

  This study is exploring a new way to treat synovial sarcoma, a type of cancer that usually affects younger people, by using a special drug called TAK-981 to target a process that helps the cancer grow, with the hope of damaging the cancer cells and reducing tumors in mice.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10897929

• Finding treatment weaknesses in synovial sarcoma cancer cells

  This study is looking at a type of cancer called synovial sarcoma to find out how certain genetic changes might make it more vulnerable to new treatments, especially by combining special therapies that target genes with those that help the immune system fight the cancer.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10848816

Related topics

Quick answers

How many Synovial Sarcoma clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), Germany (3 trials), Italy (2 trials), China (2 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 1/2: 4, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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