Condition

Nephrolithiasis clinical trials and research

• 27Clinical trials
• 9NIH research projects
• 13Countries

Newest Nephrolithiasis clinical trials

All recruiting trials (27)

• Suction vs Conventional Ureteral Access Sheaths in Kidney Stone Surgery

  This study tests whether using a suction ureteral access sheath during RIRS helps adults clear stones more often and potentially reduces operative time and infections compared with a conventional sheath.

  Recruiting Antalya Health Sciences University · Antalya, Muratpasa · NCT07866209

• Observation vs Upfront Surgery for Asymptomatic Kidney Stones in Children and Adults

  This trial tests whether watching asymptomatic kidney stones or performing upfront surgery is better for reducing life disruption in patients aged 6 and older.

  Recruiting at 2 sites Children's Hospital of Philadelphia · Irvine, California and 3 other locations · NCT07718802

• Tract Closure with Hemostatic Agent in PCNL

  This trial tests whether applying a hemostatic agent during tract closure in PCNL helps reduce blood loss compared with balloon tamponade alone.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07668817

• Suction to collapse the kidney's collecting system after RIRS (retrograde intrarenal surgery)

  This trial will test whether actively suctioning the kidney's collecting system at the end of RIRS reduces early postoperative pain and infections for adults having kidney stone removal.

  Recruiting Kangdong Sacred Heart Hospital · Gandong-gu, Outside U.S./Canada · NCT07535281

• Early versus delayed shock wave treatment for leftover kidney stones after percutaneous nephrolithotomy

  This trial tests whether doing extracorporeal shock wave lithotripsy (ESWL) early or waiting longer after PCNL helps clear leftover kidney stone fragments ≤15 mm with fewer complications.

  Recruiting Beni-Suef University · Banī Suwayf, Beni-Suef Governrate · NCT07523074

• Compare two suction ureteroscope devices for kidney stones (FANS vs CVAC)

  This study tests whether two new suction-enabled ureteroscopes (FANS and CVAC) lead to better stone clearance for adults with small to medium kidney stones compared to each other.

  Recruiting Ohio State University · Columbus, Ohio · NCT07514351

• 21-day comprehensive spa care for kidney and urinary conditions

  This program will try a 21-day spa treatment with mineral water baths, drinking cures, exercise and diet for adults 40–70 who have chronic kidney or urinary problems to see if it improves symptoms and kidney health.

  Recruiting Institute of Spa and Balneology, public research institution · Mariánské Lázně, Carlsbad Region · NCT07435844

• Comparing three single-use flexible ureteroscopes for treating kidney stones

  This compares three single-use flexible ureteroscopes to see which gives the best results for adults aged 18–60 with kidney stones smaller than 20 mm.

  Recruiting Ain Shams University · Cairo · NCT07360353

• Shock wave treatment versus flexible ureteroscopy for a single 1–2 cm kidney stone

  This research will test whether shock waves from outside the body (ESWL) or a flexible scope with laser (RIRS) works better for adults 18–65 who have a single 1–2 cm kidney stone.

  Recruiting Ziauddin Hospital · Karachi, Sindh · NCT07261995

• Prone versus supine positioning during percutaneous kidney stone removal (PCNL)

  This trial will test whether doing PCNL with the patient prone or supine gives more stable blood pressure and heart function during surgery for adults with large kidney stones.

  Recruiting Gaziosmanpasa Research and Education Hospital · Istanbul · NCT07138872

• Alpha-blockers before flexible ureteroscopy to ease ureteral access sheath placement.

  This trial will test whether taking an alpha-blocker for seven days before flexible ureteroscopy helps surgeons place the ureteral access sheath in adults with kidney stones.

  Recruiting Phase 4 Centro Universitário FMABC · Santo André, São Paulo · NCT07124299

• Ho:YAG versus thulium fiber laser for mini-PCNL with the ClearPetra suction sheath

  This trial will see if the Ho:YAG or thulium fiber laser clears kidney stones better during mini-PCNL with the ClearPetra suction sheath in adults with stones larger than 15 mm.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07087977

• Suction-assisted flexible RIRS versus PCNL for 2–3 cm kidney stones

  This study will test whether a suction-assisted flexible RIRS removes 2–3 cm kidney stones as effectively and safely as standard PCNL in adults.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT07058402

• Investigating oxalate production in patients with calcium oxalate kidney stones

  This study is testing if people with calcium oxalate kidney stones produce more oxalate in their bodies than healthy individuals by following a special diet and taking certain supplements.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06989320

• Evaluating genetic factors in patients with calcium phosphate kidney stones

  This study is testing if certain genetic factors in people with calcium phosphate kidney stones can help us understand how to prevent and manage these stones better.

  Recruiting University of Iowa · Iowa City, Iowa · NCT06974357

• Treatment of gout using potassium citrate tablets

  This study is testing if potassium citrate and sodium bicarbonate can help people with gout lower their uric acid levels and reduce flare-ups while also preventing kidney stones.

  Recruiting Phase 4 Huashan Hospital · Shanghai · NCT06966635

• Comparing two types of ureteral access sheaths for treating kidney stones

  This study is testing whether a new bendable suction tool works better than a standard tool for helping patients with kidney stones get them removed safely during a specific procedure.

  Recruiting Menoufia University · Shebin Elkom, Menoufia · NCT06862141

• Comparing two laser systems for breaking up kidney stones

  This study is testing whether a new type of laser for breaking up kidney stones works as well and as quickly as a current laser option during a minimally invasive procedure.

  Recruiting University of California, San Diego · San Diego, California · NCT06721975

• Empagliflozin and personalized diet for preventing calcium kidney stones

  This study tests whether the diabetes drug empagliflozin plus tailored dietary counseling can reduce recurrent calcium kidney stones in adults.

  Recruiting at 9 sites Phase 3 Insel Gruppe AG, University Hospital Bern · Amiens and 20 other locations · NCT06653738

• Using bupivacaine to reduce pain after ureteroscopy for kidney stones

  This study tests if using bupivacaine in the bladder after kidney stone surgery can help reduce pain and improve comfort for patients.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT06635889

• LithoVue Elite ureteroscope with real‑time kidney pressure monitoring during flexible ureteroscopy.

  This test will see if showing surgeons real‑time kidney pressure readings during flexible ureteroscopy changes how they operate and affects outcomes for adults having ureteroscopy for kidney or proximal ureter stones larger than 2 cm.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06576661

• Comparing two methods for kidney stone removal

  This study is testing whether using a special gel along with a common kidney stone removal method can help people get rid of stones more effectively than just using the method alone.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT06469736

• Investigating how the gut absorbs oxalate in kidney stone patients

  This study is trying to see if people with kidney stones absorb more oxalate from their diet than healthy individuals, which might lead to more oxalate in their urine.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06331546

• Using gut bacteria to reduce urinary oxalate in kidney stone patients

  This study is testing if introducing a specific gut bacteria can help adults with calcium oxalate kidney stones lower the amount of oxalate in their urine.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06330246

• Predicting kidney stone recurrence and complications using precision medicine

  This study is trying to find out what causes kidney stones to come back so that we can help people avoid getting them again.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05237063

• Imaging kidney sodium levels using MRI

  This study is testing if a special MRI can show differences in sodium levels in the kidneys of people with various kidney diseases to help improve their treatment.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05014178

• Using blood tests to predict infections after kidney stone surgery

  This study is testing if blood tests can help predict which adults are more likely to get infections after kidney stone surgery.

  Recruiting University of Miami · Miami, Florida · NCT04669886

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving kidney stone management in young patients

  This study is all about finding better ways to help kids and young adults under 21 who have kidney stones, by learning more about how these stones develop and how they feel after surgery, so we can create personalized treatment plans just for them.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159844

• Improving outcomes for children with kidney stones

  This study is all about helping kids with kidney stones by bringing together top children's hospitals to share ideas and resources, so we can find better ways to treat and manage this condition for healthier futures.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159841

• Improving kidney stone treatment for children

  This study is all about finding better ways to help kids with kidney stones feel better and get the right treatment, while also supporting new researchers who want to make a difference in this area.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159839

• Understanding how bacteria contribute to kidney stone formation

  This study is looking at how certain bacteria that form biofilms might help create kidney stones, which many people deal with, to find new ways to prevent and treat this common problem.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11081818

• Understanding how citrate and oxalate levels affect kidney stones

  This study is looking at how what we eat affects the levels of citrate and oxalate in the urine, which are important for preventing kidney stones, especially for people who are obese or have had gastric bypass surgery, to help create better ways to keep your kidneys healthy.

  NIH research University of Chicago · Chicago, United States · NIH-11081754

• Understanding how calcium signaling affects kidney stone formation

  This study is looking at how calcium levels and acidity in the kidneys affect the formation of calcium-based kidney stones, with the hope of finding new ways to help people prevent these stones from forming.

  NIH research U.s. Dept/vets Affairs Medical Center · Washington, United States · NIH-11050052

• Improving kidney stone management in young patients

  This study is all about finding better ways to help kids and young adults under 21 who have kidney stones, by learning more about how these stones develop and how they feel after surgery, so we can create tailored treatment plans just for them.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10953811

• Improving kidney stone outcomes in children

  This study is all about finding better ways to help kids with kidney stones by working together with top children's hospitals, and it also helps new researchers learn more about treating this condition.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10953810

• New treatment for high oxalate levels and kidney stones

  This study is looking at a new way to help people with hyperoxaluria, a condition that can cause kidney stones, by blocking a protein in the colon that makes the body absorb too much oxalate, so that more oxalate can be removed through stool instead of ending up in the urine.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10877183

Related topics

Quick answers

How many Nephrolithiasis clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (12 trials), Egypt (3 trials), France (2 trials), Germany (2 trials), Turkey (Türkiye) (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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