Alpha-blockers before flexible ureteroscopy to ease ureteral access sheath placement.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized prospective phase 4 trial enrolling adults with nephrolithiasis who are scheduled for flexible ureterorenolithotripsy at Centro Universitário FMABC. Participants are randomly assigned to receive an alpha-blocker for seven days before surgery or to proceed without preoperative alpha-blocker therapy. The primary outcome is successful ureteral access sheath placement without the need for a second procedure, and secondary outcomes include ureteral injury rates and the need for additional surgical interventions. The trial tests whether short-term pharmacologic relaxation of the ureter improves intraoperative efficiency and patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Diagnosis of nephrolithiasis with surgical indication for flexible ureterorenolithotripsy
* Ability to provide written informed consent

Exclusion Criteria:

* Age \< 18 years
* Pregnancy
* History of ureteral stricture, prior ureteral reconstructive surgery, and/or abdominal or pelvic radiotherapy
* Prior ureteroscopy or ipsilateral double-J stent placement within the past 3 months
* Chronic use of alpha-blockers for benign prostatic hyperplasia or medical expulsive therapy for ureteral stones

Where it's running

• Centro Universitário FMABC
  Santo André, São Paulo, Brazil Recruiting

Study contacts

• Study coordinator: Pedro FB Buchalla, MD
• Email: pedrofbuchalla@gmail.com
• Phone: +5516997704207

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Suction vs Conventional Ureteral Access Sheaths in Kidney Stone Surgery

  This study tests whether using a suction ureteral access sheath during RIRS helps adults clear stones more often and potentially reduces operative time and infections compared with a conventional sheath.

  Recruiting Antalya Health Sciences University · Antalya, Muratpasa · NCT07866209

• Long-term safety of UAS-assisted vs sheathless RIRS in adults with kidney stones

  This study tests whether using a ureteral access sheath during the initial RIRS affects long-term safety and outcomes in adults with kidney stones ≤20 mm.

  Recruiting Al-Azhar University · Cairo · NCT07767773

• Observation vs Upfront Surgery for Asymptomatic Kidney Stones in Children and Adults

  This trial tests whether watching asymptomatic kidney stones or performing upfront surgery is better for reducing life disruption in patients aged 6 and older.

  Recruiting at 2 sites Children's Hospital of Philadelphia · Irvine, California and 3 other locations · NCT07718802

• Tract Closure with Hemostatic Agent in PCNL

  This trial tests whether applying a hemostatic agent during tract closure in PCNL helps reduce blood loss compared with balloon tamponade alone.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07668817

• Suction to collapse the kidney's collecting system after RIRS (retrograde intrarenal surgery)

  This trial will test whether actively suctioning the kidney's collecting system at the end of RIRS reduces early postoperative pain and infections for adults having kidney stone removal.

  Recruiting Kangdong Sacred Heart Hospital · Gandong-gu, Outside U.S./Canada · NCT07535281

• Early versus delayed shock wave treatment for leftover kidney stones after percutaneous nephrolithotomy

  This trial tests whether doing extracorporeal shock wave lithotripsy (ESWL) early or waiting longer after PCNL helps clear leftover kidney stone fragments ≤15 mm with fewer complications.

  Recruiting Beni-Suef University · Banī Suwayf, Beni-Suef Governrate · NCT07523074

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.