Understanding how citrate and oxalate levels affect kidney stones
Mechanisms of disordered citrate and oxalate excretion in nephrolithiasis
This study is looking at how what we eat affects the levels of citrate and oxalate in the urine, which are important for preventing kidney stones, especially for people who are obese or have had gastric bypass surgery, to help create better ways to keep your kidneys healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11081754 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the excretion of citrate and oxalate in the kidneys, which are crucial for preventing kidney stones. It focuses on two high-risk patient groups: those with obesity and individuals who have undergone Roux-en-Y gastric bypass surgery. By examining how diet influences urine citrate and oxalate levels, the study aims to develop better prevention strategies for kidney stones. The findings could lead to new dietary recommendations and treatments that improve kidney health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with obesity or those who have had Roux-en-Y gastric bypass surgery.
Not a fit: Patients who do not have issues with kidney stones or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for kidney stones, reducing pain and healthcare costs for patients.
How similar studies have performed: Previous research has shown promising results in understanding dietary impacts on kidney stone formation, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Prochaska, Megan L — University of Chicago
- Study coordinator: Prochaska, Megan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.