Understanding how citrate and oxalate levels affect kidney stones
Official title: Mechanisms of disordered citrate and oxalate excretion in nephrolithiasis
Funded at University of Chicago · NIH-11081754 · Data updated 2026-11-12
This study is looking at how what we eat affects the levels of citrate and oxalate in the urine, which are important for preventing kidney stones, especially for people who are obese or have had gastric bypass surgery, to help create better ways to keep your kidneys healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 1, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $185,976 |
| NIH project number | 5K23DK127252-04 |
| Project ID | NIH-11081754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with obesity or those who have had Roux-en-Y gastric bypass surgery.
✕Less likely to help
Patients who do not have issues with kidney stones or related metabolic conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate the excretion of citrate and oxalate in the kidneys, which are crucial for preventing kidney stones. It focuses on two high-risk patient groups: those with obesity and individuals who have undergone Roux-en-Y gastric bypass surgery. By examining how diet influences urine citrate and oxalate levels, the study aims to develop better prevention strategies for kidney stones. The findings could lead to new dietary recommendations and treatments that improve kidney health.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for kidney stones, reducing pain and healthcare costs for patients.
How similar studies have gone: Previous research has shown promising results in understanding dietary impacts on kidney stone formation, indicating that this approach has potential for success.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Prochaska, Megan L — University of Chicago
- Study coordinator: Prochaska, Megan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.