Condition

Urolithiasis clinical trials and research

• 24Clinical trials
• 3NIH research projects
• 1New in 30 days
• 9Countries

Newest Urolithiasis clinical trials

All recruiting trials (24)

• Acupressure to Ease Pain During ESWL for Kidney Stones

  This study tests whether applying acupressure to specific points before ESWL can reduce pain and improve comfort for adults with kidney or proximal ureteral stones.

  Recruiting Medipol University · Istanbul · NCT07885696

• Audio consent with human voice or AI-voice added to written consent for ureteroscopy

  This study tests if listening to an audio version of the consent form, read by a real urologist or by an AI-cloned voice, helps adults in Turkey understand their ureteroscopy or RIRS consent better than the written form alone.

  Recruiting at 3 sites Aydin Adnan Menderes University · Aydin, Aydın and 2 other locations · NCT07859436

• Norepinephrine irrigation to help stop bleeding during flexible ureteroscopic lithotripsy

  This study tests whether a norepinephrine-powered irrigation solution can help control bleeding during flexible ureteroscopic lithotripsy for upper urinary tract stones in adults.

  Recruiting Phase 1/2 Geriatric Hospital of Nanjing Medical University · Nanjing, Jiangsu · NCT07786844

• Long-term safety of UAS-assisted vs sheathless RIRS in adults with kidney stones

  This study tests whether using a ureteral access sheath during the initial RIRS affects long-term safety and outcomes in adults with kidney stones ≤20 mm.

  Recruiting Al-Azhar University · Cairo · NCT07767773

• See if pelvic floor endurance relates to stent symptoms after ureteroscopy

  This study tests whether a ultrasound measure of pelvic floor endurance (PFFI) can predict ureteral stent-related symptoms after ureteroscopy or RIRS in adults 18–65.

  Recruiting Trabzon Kanuni Education and Research Hospital · Trabzon, Trabzon · NCT07763613

• Aspiration-enabled vs conventional ureteral access sheath for RIRS in kidney stone patients

  This study tests whether using an aspiration-enabled access sheath during retrograde intrarenal surgery (RIRS) helps prevent early kidney injury compared with conventional sheaths in adults with kidney stones.

  Recruiting Namik Kemal University · Tekirdağ · NCT07685587

• Gentamicin Irrigation and Suction Ureteral Access in Kidney Stone Surgery

  This trial tests whether using gentamicin-containing irrigation fluid and a suction-enabled ureteral access sheath during retrograde intrarenal surgery (RIRS) can lower fever, SIRS, and sepsis after kidney stone treatment.

  Recruiting Hitit University · Çorum, Çorum and 1 other locations · NCT07655050

• ComfiJ vs. standard double-J stent after ureteroscopy or RIRS

  This trial tests whether a ComfiJ ureteral stent causes fewer urinary symptoms than a conventional double-J stent in adults needing short-term stenting after ureteroscopy or RIRS for stones.

  Recruiting at 3 sites Beni-Suef University · Banī Suwayf, Beni Suweif Governorate and 2 other locations · NCT07627828

• Two-Tier Virtual Reality Education to Reduce Anxiety Before Kidney Stone Surgery

  This study tests whether a two-tier VR preoperative education approach can lower anxiety and improve knowledge and self-care in adults undergoing urolithiasis surgery.

  Recruiting Chang Gung Memorial Hospital · Keelung · NCT07620873

• L-Citrulline vs Tamsulosin for Helping Distal Ureteral Stones Pass

  This study tests whether L-citrulline helps stones pass from the distal ureter as well as or better than tamsulosin in adults with a single 5–10 mm stone.

  Recruiting Phase 2 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07617909

• Quality of life with a modified Double-J ureteral stent

  This trial tests whether a modified Double-J stent with a thinner bladder-end loop reduces stent-related symptoms and improves quality of life for adults having ureteroscopy for kidney or ureteral stones.

  Recruiting St. Luke's Clinical Hospital, Russia · Saint Petersburg, Outside U.S./Canada · NCT07275879

• MODULITH SLX-F2 shockwave treatment with StorM-Track versus standard targeting for kidney stones

  This will test if using StorM-Track real-time stone tracking with the MODULITH SLX-F2 shockwave machine helps adults with 6–15 mm kidney stones become stone-free more often than standard shockwave treatment.

  Recruiting Storz Medical AG · Stockholm · NCT07272720

• Antibiotics versus no antibiotics for flexible ureteroscopy with a negative-pressure suction sheath

  This trial will test whether adults at low risk of infection having single-use flexible ureteroscopy with a negative-pressure suction sheath can safely skip the usual single-dose antibiotic before surgery.

  Recruiting Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07246967

• Stone clearance with steerable ureteroscopic evacuation compared with other methods

  This study tests whether the CVAC/SURE approach helps clear kidney stones more effectively than standard renal-stone interventions in patients needing ureteroscopy or PCNL.

  Recruiting at 10 sites Calyxo, Inc. · Miami, Florida and 9 other locations · NCT07155005

• Steerable Ureteroscopic Renal Evacuation (SURE) with CVAC vs standard ureteroscopy

  This trial tests whether the SURE system with CVAC can improve outcomes compared with standard ureteroscopy with laser lithotripsy for kidney stones in adult patients.

  Recruiting at 6 sites Calyxo, Inc. · Birmingham, Alabama and 5 other locations · NCT07101809

• Comparing robotic and manual methods for treating kidney stones

  This study is testing whether a robotic system works better than traditional manual methods for treating kidney stones to see which approach is safer and more effective for adults.

  Recruiting American University of Beirut Medical Center · Beirut · NCT06996587

• Investigating oxalate production in patients with calcium oxalate kidney stones

  This study is testing if people with calcium oxalate kidney stones produce more oxalate in their bodies than healthy individuals by following a special diet and taking certain supplements.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06989320

• Comparing different flexible ureteroscopes for treating kidney stones

  This study is testing which size of flexible ureteroscope works best for treating kidney stones in adults aged 18 to 80.

  Recruiting Ningbo No. 1 Hospital · Ningbo, Zhejiang · NCT06987760

• Impact of urine culture timing on outcomes after kidney stone surgery

  This study looks at whether taking urine samples two weeks before kidney stone surgery helps prevent infections better than taking them closer to the surgery date.

  Recruiting Namik Kemal University · Tekirdağ · NCT06723327

• Comparing anti-reflux stents and standard stents in children with kidney stones

  This study is testing if special anti-reflux stents can help children with kidney stones recover better and have fewer complications after surgery compared to regular stents.

  Recruiting The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT06569173

• Investigating how the gut absorbs oxalate in kidney stone patients

  This study is trying to see if people with kidney stones absorb more oxalate from their diet than healthy individuals, which might lead to more oxalate in their urine.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06331546

• Using gut bacteria to reduce urinary oxalate in kidney stone patients

  This study is testing if introducing a specific gut bacteria can help adults with calcium oxalate kidney stones lower the amount of oxalate in their urine.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06330246

• Using intra-nasal ketorolac to relieve pain from ureteral stents after ureteroscopy

  This study is testing whether a nasal spray of ketorolac can help relieve pain better than oral diclofenac for patients with ureteral stents after surgery.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06158620

• International registry for renal stone treatment outcomes

  This study is trying to see how different surgical treatments for kidney stones work and what factors affect their success, so doctors can choose the best options for their patients.

  Recruiting at 3 sites Chinese University of Hong Kong · Hong Kong and 2 other locations · NCT05297331

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• sipIT digital support to help people with kidney stones drink more

  This project offers a phone-based sipIT tool to help people with kidney stones drink enough fluid to reach about 2.5 liters of urine per day.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11141318

• Increasing urine output in patients with kidney stones using a digital tool.

  This study is testing a helpful app called sipIT that reminds people with kidney stones to drink more fluids, making it easier for them to stay hydrated and prevent future stones.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-10893454

• Understanding the causes of excess acid in kidney stones

  This study is looking into how gut bacteria and liver health might cause uric acid kidney stones, which are becoming more common, especially in people with obesity and diabetes, to help find better treatments for those who suffer from them.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10696033

Related topics

Quick answers

How many Urolithiasis clinical trials are recruiting right now?

24, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Turkey (Türkiye) (6 trials), United States (6 trials), China (4 trials), Egypt (3 trials), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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