Treatment of gout using potassium citrate tablets
Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets
This study is testing if potassium citrate and sodium bicarbonate can help people with gout lower their uric acid levels and reduce flare-ups while also preventing kidney stones.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 312 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Huashan Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT06966635 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of alkalization on lowering uric acid levels and reducing gout flare-ups, as well as its potential role in preventing urinary stones in gout patients. Participants are divided into three groups: one receiving potassium citrate, another receiving sodium bicarbonate, and a control group receiving standard uric acid-lowering treatments. Each alkalization group takes their respective treatment three times a day alongside their standard regimen. The study aims to determine the efficacy of these alkalization treatments in managing gout and related conditions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 who meet the diagnostic criteria for gout and have stable uric acid-lowering treatment.
Not a fit: Patients experiencing an acute gout flare or those with secondary gout due to other medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new approach to managing gout and preventing related complications.
How similar studies have performed: Other studies have explored alkalization for gout management, but this specific approach with potassium citrate is less common and may offer novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet the diagnostic criteria of the American College of Rheumatology (ACR) and the European League against Rheumatism (EULAR) for gout in 2015 * Age 18-70 years old, gender is not limited * The interval between the most recent acute onset of gout is at least \> 2 weeks * Routine treatment with stable dose of uric-lowering drugs for \> 4 weeks * For women who are likely to become pregnant, pregnancy tests must be negative, they must not be lactating, they must be using an investigator-approved method of contraception, and they must agree to maintain this method of contraception throughout the study * Study participants were informed, voluntarily signed informed consent, and agreed to participate in all visits, examinations, and treatments as required by the trial protocol * Informed consent to the purpose and content of the research. Exclusion Criteria: * Acute gout flare * Secondary gout caused by kidney disease, blood disease, or taking certain drugs, tumor radiotherapy and chemotherapy * Severe and unstable cardiovascular and cerebrovascular diseases (such as unstable angina pectoris, coronary angiogenesis, cerebral angiogenesis, transient ischemic attack, congestive heart failure, etc.), acute and difficult to control diseases, chronic diffuse connective tissue disease, xanthine urethral deposition, Lesch-Nyhan syndrome, untreated thyroid disease or kidney stones, treatment Patients with severe hypertension (blood pressure \> 160/100mmHg) or diabetes (fasting blood glucose \> 11.1mmol/L) and organ transplantation that were not effectively controlled later * People who are allergic, have a history of allergy to test-related drugs (febuxosita tablets, allopurinol tablets, benzbromarone, etoracoxib, colchicine, potassium citrate, etc.) or are allergic to test-related drug components * Active peptic ulcer or ulcer with bleeding and perforation, severe chronic diarrhea or recurrent skin disease in the past year * Blood white blood cell count \< 3.0x109/L, hemoglobin \< 90g/L, platelet count \< 100x109/L, or other blood system diseases (such as severe anemia, idiopathic thrombocytopenic purpura, spleen enlargement, coagulation dysfunction, etc.) * Active stage of liver disease or abnormal liver function (ALT or AST≥2 times the upper limit of normal) * Patients with abnormal renal function (eGFR≤60ml/min/1.73m\^2) * Patients with elevated blood potassium (5.5mmol/L) may have diseases or factors that may lead to hyperkalemia, such as type IV renal tubular acidosis and widespread tissue injury * Urine PH value \> 6.5 during screening * Combined use of the following drugs: Contains salicylate drugs such as aspirin (\> 300mg/d), thiazide diuretics, potassium diuretics such as amphenopterine, Amiloride, ACEI, azathioprine, 6-mercaptopurine, theophylline, losartan, cyclosporin A, cyclophospfamide, pyrazinamide, glucocorticoid (except in acute episodes), Niergoline tablets, long-term use of insulin, Digitalis * Women who are pregnant, planning to become pregnant or breastfeeding mental illness, no self-knowledge, unable to accurately express or can not take drugs on time * A history of alcohol abuse or dependence on known drugs within the last two years * Those who have participated or are participating in other clinical trials within three months * The study participant is a family member or relative of the staff of the research Center * Other lesions or conditions that, in the investigator's judgment, reduce or complicate enrollment.
Where this trial is running
Shanghai
- Huashan hospital, Fudan university — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Yu Miao
- Email: my20000109@126.com
- Phone: 021-17857540080
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.