NIH-funded research NIH-funded research

Improving kidney stone management in young patients

Official title: Personalizing Outcomes of Nephrolithiasis in Youth (PONY) Research Project

Funded at Children's Hosp of Philadelphia · NIH-10953811 · Data updated 2026-11-12

This study is all about finding better ways to help kids and young adults under 21 who have kidney stones, by learning more about how these stones develop and how they feel after surgery, so we can create tailored treatment plans just for them.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionChildren's Hosp of Philadelphia
NIH-funded
Lab location1 site (Philadelphia, United States)
Project startAugust 1, 2024
Project endMay 31, 2027
Funding year2024
Award (this year)$393,517
NIH project number1P20DK140504-01
Project IDNIH-10953811 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include youth aged 0 to 21 who have experienced kidney stones or are at risk for developing them.

Less likely to help

Patients over the age of 21 or those without a history of kidney stones may not benefit from this research.

What this research studies

This research focuses on understanding and improving the management of kidney stones in youth aged 21 years and younger. It aims to gather new insights into the natural progression of non-obstructive kidney stones and the experiences of patients after undergoing ureteroscopy surgery. By collaborating with multiple children's hospitals, the project seeks to develop personalized treatment strategies based on patient-centered knowledge. The research will utilize existing data and partnerships to enhance care for young patients suffering from this chronic condition.

Why it matters

Potential benefit: If successful, this research could lead to more effective and personalized treatment options for young patients with kidney stones.

How similar studies have gone: Previous research has shown promise in improving management strategies for chronic conditions in pediatric populations, indicating potential success for this approach.

Where this research is happening

  • Children's Hosp of Philadelphia
    Philadelphia, United States
    Active

Researchers

  • Principal investigator: Chu, David — Children's Hosp of Philadelphia
  • Study coordinator: Chu, David

Related research

Other NIH-funded projects on the same topics.

  • Improving kidney stone management in young patients

    This study is all about finding better ways to help kids and young adults under 21 who have kidney stones, by learning more about how these stones develop and how they feel after surgery, so we can create personalized treatment plans just for them.

    NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159844

  • Improving outcomes for children with kidney stones

    This study is all about helping kids with kidney stones by bringing together top children's hospitals to share ideas and resources, so we can find better ways to treat and manage this condition for healthier futures.

    NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159841

  • Improving kidney stone treatment for children

    This study is all about finding better ways to help kids with kidney stones feel better and get the right treatment, while also supporting new researchers who want to make a difference in this area.

    NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159839

  • Understanding how bacteria contribute to kidney stone formation

    This study is looking at how certain bacteria that form biofilms might help create kidney stones, which many people deal with, to find new ways to prevent and treat this common problem.

    NIH research University of California Los Angeles · Los Angeles, United States · NIH-11081818

  • Understanding how citrate and oxalate levels affect kidney stones

    This study is looking at how what we eat affects the levels of citrate and oxalate in the urine, which are important for preventing kidney stones, especially for people who are obese or have had gastric bypass surgery, to help create better ways to keep your kidneys healthy.

    NIH research University of Chicago · Chicago, United States · NIH-11081754

  • Understanding how calcium signaling affects kidney stone formation

    This study is looking at how calcium levels and acidity in the kidneys affect the formation of calcium-based kidney stones, with the hope of finding new ways to help people prevent these stones from forming.

    NIH research U.s. Dept/vets Affairs Medical Center · Washington, United States · NIH-11050052

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.