NIH-funded research NIH-funded research

Improving kidney stone treatment for children

Official title: Personalizing Outcomes of Nephrolithiasis in Youth (PONY)

Funded at Children's Hosp of Philadelphia · NIH-11159839 · Data updated 2026-11-12

This study is all about finding better ways to help kids with kidney stones feel better and get the right treatment, while also supporting new researchers who want to make a difference in this area.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionChildren's Hosp of Philadelphia
NIH-funded
Lab location1 site (Philadelphia, United States)
Project startAugust 1, 2024
Project endMay 31, 2027
Funding year2025
Award (this year)$391,028
NIH project number5P20DK140504-02
Project IDNIH-11159839 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are children aged 0-11 years who have been diagnosed with kidney stone disease.

Less likely to help

Patients outside the age range of 0-11 years or those without a diagnosis of kidney stone disease may not benefit from this research.

What this research studies

This research focuses on enhancing the understanding and management of kidney stone disease in children, which is becoming more common. By collaborating with various experts and utilizing existing data resources, the project aims to identify effective treatment strategies tailored to the unique needs of young patients. The initiative also seeks to support early-stage researchers in the field, fostering innovation and improving care for pediatric patients suffering from this painful condition.

Why it matters

Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children with kidney stones, reducing pain and recurrence.

How similar studies have gone: Previous research has shown promise in improving outcomes for pediatric kidney stone disease, indicating that this approach could build on existing knowledge.

Where this research is happening

  • Children's Hosp of Philadelphia
    Philadelphia, United States
    Active

Researchers

  • Principal investigator: Tasian, Gregory Edward — Children's Hosp of Philadelphia
  • Study coordinator: Tasian, Gregory Edward

Related research

Other NIH-funded projects on the same topics.

  • Improving kidney stone management in young patients

    This study is all about finding better ways to help kids and young adults under 21 who have kidney stones, by learning more about how these stones develop and how they feel after surgery, so we can create personalized treatment plans just for them.

    NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159844

  • Improving outcomes for children with kidney stones

    This study is all about helping kids with kidney stones by bringing together top children's hospitals to share ideas and resources, so we can find better ways to treat and manage this condition for healthier futures.

    NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11159841

  • Understanding how bacteria contribute to kidney stone formation

    This study is looking at how certain bacteria that form biofilms might help create kidney stones, which many people deal with, to find new ways to prevent and treat this common problem.

    NIH research University of California Los Angeles · Los Angeles, United States · NIH-11081818

  • Understanding how citrate and oxalate levels affect kidney stones

    This study is looking at how what we eat affects the levels of citrate and oxalate in the urine, which are important for preventing kidney stones, especially for people who are obese or have had gastric bypass surgery, to help create better ways to keep your kidneys healthy.

    NIH research University of Chicago · Chicago, United States · NIH-11081754

  • Understanding how calcium signaling affects kidney stone formation

    This study is looking at how calcium levels and acidity in the kidneys affect the formation of calcium-based kidney stones, with the hope of finding new ways to help people prevent these stones from forming.

    NIH research U.s. Dept/vets Affairs Medical Center · Washington, United States · NIH-11050052

  • Improving kidney stone management in young patients

    This study is all about finding better ways to help kids and young adults under 21 who have kidney stones, by learning more about how these stones develop and how they feel after surgery, so we can create tailored treatment plans just for them.

    NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10953811

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.