New treatment for high oxalate levels and kidney stones
Official title: SLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and Nephrolithiasis
Funded at University of California, San Francisco · NIH-10877183 · Data updated 2026-11-12
This study is looking at a new way to help people with hyperoxaluria, a condition that can cause kidney stones, by blocking a protein in the colon that makes the body absorb too much oxalate, so that more oxalate can be removed through stool instead of ending up in the urine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 22, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $310,080 |
| NIH project number | 5R01DK126070-05 |
| Project ID | NIH-10877183 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hyperoxaluria, particularly those with a history of kidney stones or chronic kidney disease.
✕Less likely to help
Patients who do not have elevated oxalate levels or related kidney conditions may not benefit from this research.
What this research studies
This research investigates a novel approach to treat hyperoxaluria, a condition characterized by high levels of oxalate in the urine that can lead to kidney stones and chronic kidney disease. The study focuses on inhibiting a specific protein, SLC26A3, in the colon that facilitates the absorption of oxalate, thereby promoting its excretion through stool. By blocking this protein, the researchers aim to reduce the amount of oxalate that enters the urine, potentially alleviating the risk of kidney stone formation and protecting kidney function. The research utilizes both animal models and human data to explore the effectiveness of these inhibitors.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients suffering from hyperoxaluria and related kidney issues.
How similar studies have gone: Previous research has shown promising results with similar approaches targeting oxalate absorption, suggesting potential for success in this novel treatment strategy.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Cil, Onur — University of California, San Francisco
- Study coordinator: Cil, Onur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.