Prone versus supine positioning during percutaneous kidney stone removal (PCNL)
Official title: The Effect of Surgical Position on Hemodynamics in Percutaneous Nephrolithotomy Performed in Prone and Supine Positions
Run by Gaziosmanpasa Research and Education Hospital · NCT07138872 · Data updated 2026-11-12
This trial will test whether doing PCNL with the patient prone or supine gives more stable blood pressure and heart function during surgery for adults with large kidney stones.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 84 (estimated) |
| Sponsor | Gaziosmanpasa Research and Education Hospital Government |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | December 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | August 24, 2025 |
| Trial ID | NCT07138872 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with renal calculi appropriate for PCNL and ASA physical status I–III who are scheduled for elective single-tract PCNL and meet the study's eligibility criteria are ideal candidates.
✕Probably not a fit
Patients who are pregnant, have uncontrolled coagulopathy, prior renal surgery, severe cardiac, pulmonary, or neurological disease, active urinary infection, require multiple access tracts, had a recent preoperative transfusion, or whose surgery is expected to last under 60 minutes or over 120 minutes are excluded and unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will enroll 84 adults (18–80 years, ASA I–III) undergoing elective percutaneous nephrolithotomy and randomly assign them to prone or supine (Galdakao-modified Valdivia) positioning. Intraoperative and postoperative hemodynamic parameters (blood pressure, heart rate, and related measures) will be recorded and compared between groups. Patients with pregnancy, uncontrolled coagulopathy, prior renal surgery, severe cardiorespiratory or neurologic disease, active urinary infection, or specified operative exclusions are not eligible. Results aim to clarify whether one position provides more stable cardiovascular status during and after PCNL and to inform position choice for patients at hemodynamic risk.
Why it matters
Potential benefit: If successful, the trial could identify the positioning approach that reduces intraoperative cardiovascular instability and perioperative complications, improving safety for patients with large kidney stones.
How similar studies have gone: Prior physiologic studies and small series suggest prone positioning can raise intrathoracic pressure and reduce venous return while supine may be more hemodynamically stable, but direct comparative randomized data are limited and remain inconclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA physical status I-III * Presence of renal calculi indicated for PNL Exclusion Criteria: * Pregnancy * Uncontrolled coagulopathy * Previous renal surgery * Severe cardiac, pulmonary, or neurological disease * Preoperative urinary tract infection (non-sterile urine culture) * Surgery duration \<60 minutes or \>120 minutes * Preoperative blood transfusion * Multiple access tracts
Where it's running
-
Gaziosmanpaşa Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ari̇f Burak Keçebaş, Urology Clinic Doctor
- Email: arifkecebas@gmail.com
- Phone: +90 5412659978
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.