Condition

Kidney Stone clinical trials and research

• 24Clinical trials
• 18NIH research projects
• 9Countries

Newest Kidney Stone clinical trials

All recruiting trials (24)

• Emergency urinary drainage followed by PCNL in obstructive urosepsis

  Doctors test whether the method of emergency drainage (retrograde ureteral stent or percutaneous nephrostomy) affects how well patients do after undergoing definitive PCNL.

  Recruiting Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07826325

• Observation vs Upfront Surgery for Asymptomatic Kidney Stones in Children and Adults

  This trial tests whether watching asymptomatic kidney stones or performing upfront surgery is better for reducing life disruption in patients aged 6 and older.

  Recruiting at 2 sites Children's Hospital of Philadelphia · Irvine, California and 3 other locations · NCT07718802

• Two-Tier Virtual Reality Education to Reduce Anxiety Before Kidney Stone Surgery

  This study tests whether a two-tier VR preoperative education approach can lower anxiety and improve knowledge and self-care in adults undergoing urolithiasis surgery.

  Recruiting Chang Gung Memorial Hospital · Keelung · NCT07620873

• Tamsulosin 0.4 mg with Tadalafil 5 mg versus 2.5 mg to reduce symptoms from ureteral stents

  This will test whether adding Tadalafil at 5 mg or 2.5 mg to Tamsulosin 0.4 mg better reduces stent-related symptoms for adults with a double-J ureteral stent after stone removal.

  Recruiting Ain Shams University · Cairo, Abbasia · NCT07562282

• Ureteral access sheath: omitting versus placing a stent after ureteroscopy

  We will test if leaving out a ureteral stent after ureteroscopy with an access sheath works as well as placing a stent for pre-stented adults with kidney or ureteral stones.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07297953

• Using a flexible suction sheath with flexible ureteroscopy for lower-pole kidney stones

  This trial will test whether adding a flexible, navigable suction sheath to flexible ureteroscopy helps adults with lower-pole kidney stones become stone-free more often and avoid repeat procedures.

  Recruiting Zagazig University · Zagazig · NCT07238803

• Ho:YAG versus thulium fiber laser for mini-PCNL with the ClearPetra suction sheath

  This trial will see if the Ho:YAG or thulium fiber laser clears kidney stones better during mini-PCNL with the ClearPetra suction sheath in adults with stones larger than 15 mm.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07087977

• VISOR for removing 1–3 cm kidney and ureter stones

  This will test a new device called VISOR to break up and remove 1–3 cm kidney or ureter stones in adults aged 18–80.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07071948

• Potassium citrate effects on kidney handling of oxalate and citrate in adults

  This project will test whether a single oral dose of potassium citrate changes how the kidneys handle oxalate and citrate in adults with and without calcium oxalate kidney stones.

  Recruiting University of Chicago · Chicago, Illinois · NCT06944223

• New shaped ureteric stent for people with kidney stones or cancer-related ureter blockage compared with a conventional JJ stent

  This tests a new ureteric stent with specially shaped side-holes to see if adults needing stents for kidney stones or cancer have less blockage, infection, pain, and antibiotic use.

  Recruiting at 2 sites University of Southampton · Southampton, England and 1 other locations · NCT06815120

• Empagliflozin and personalized diet for preventing calcium kidney stones

  This study tests whether the diabetes drug empagliflozin plus tailored dietary counseling can reduce recurrent calcium kidney stones in adults.

  Recruiting at 9 sites Phase 3 Insel Gruppe AG, University Hospital Bern · Amiens and 20 other locations · NCT06653738

• LithoVue Elite ureteroscope with real‑time kidney pressure monitoring during flexible ureteroscopy.

  This test will see if showing surgeons real‑time kidney pressure readings during flexible ureteroscopy changes how they operate and affects outcomes for adults having ureteroscopy for kidney or proximal ureter stones larger than 2 cm.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06576661

• Exploring the link between kidney stones, insulin resistance, and inflammation

  This study is trying to see if people with kidney stones have more belly fat and inflammation compared to healthy individuals, to better understand how these factors are linked.

  Recruiting University of Chicago · Chicago, Illinois · NCT06436235

• Investigating how the gut absorbs oxalate in kidney stone patients

  This study is trying to see if people with kidney stones absorb more oxalate from their diet than healthy individuals, which might lead to more oxalate in their urine.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06331546

• Using gut bacteria to reduce urinary oxalate in kidney stone patients

  This study is testing if introducing a specific gut bacteria can help adults with calcium oxalate kidney stones lower the amount of oxalate in their urine.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06330246

• Impact of a DASH diet on kidney stone risk factors

  This study tests if following a DASH-style diet can lower the risk of kidney stones in people who have already had them.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06210009

• Using indapamide and chlorthalidone to prevent kidney stones

  This study is testing whether two long-lasting medications, indapamide and chlorthalidone, can help prevent kidney stones better than a shorter-acting medication called hydrochlorothiazide.

  Recruiting Phase 2 Insel Gruppe AG, University Hospital Bern · Bern · NCT06111885

• Comparing two methods for kidney stone surgery

  This study is testing two different ways to perform kidney stone surgery to see which method works better for patients.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05993546

• Forced diuresis with furosemide to reduce leftover stone fragments after flexible ureteroscopy

  This trial will try a single dose of furosemide plus IV fluids during flexible ureteroscopy to see if it lowers the amount of leftover kidney stone fragments in adults having laser stone treatment.

  Recruiting at 9 sites Phase 3 University Hospital, Tours · Angers and 8 other locations · NCT05916963

• Ureteral Drainage After Flexible URS for Kidney Stones: External Catheter vs Internal Stent

  This study tests whether a one-day external ureteral catheter works as well as a standard internal stent after a flexible ureteroscopy for kidney stones in adults.

  Recruiting Al-Azhar University · Cairo · NCT05738304

• Understanding how oxalate affects kidney stone formation in bariatric surgery candidates

  This study is testing how a low-oxalate diet affects kidney stone formation in people who are planning to have weight loss surgery and those who already have kidney stones.

  Recruiting University of Chicago · Chicago, Illinois · NCT05356000

• Effects of oxalate and citrate on kidney stone formation

  This study tests how drinking a special beverage with oxalate affects kidney stone formation in people and whether diet plays a big role in this process.

  Recruiting University of Chicago · Chicago, Illinois · NCT05334979

• Predicting kidney stone recurrence and complications using precision medicine

  This study is trying to find out what causes kidney stones to come back so that we can help people avoid getting them again.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05237063

• Evaluating Ketorolac for reducing symptoms after ureteral stent placement

  This study is testing if giving a pain medication called Ketorolac before placing a ureteral stent can help reduce discomfort and inflammation for people with kidney stones.

  Recruiting Early Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT03638999

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Uromodulin and peptides as new targets in kidney stone biology

  This NIH grant explores how a urine protein called uromodulin and its peptide pieces influence calcium oxalate kidney stones, using dogs and human biology to understand why stones form and how to prevent them.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11433374

• Oxalate‑eating probiotic to help prevent kidney stones

  A new probiotic strain is being developed to help prevent calcium oxalate kidney stones by breaking down oxalic acid in the gut.

  NIH research Unlocked Labs INC. · Laramie, United States · NIH-11364194

• Oxalate and your immune system in kidney stones

  This grant looks at how oxalate in our diet affects kidney stone risk and our immune cells, especially in adults with calcium oxalate stones.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11359754

• How the kidney channel claudin‑2 affects calcium balance and calcium kidney stones

  This project looks at how a kidney channel called claudin‑2 helps keep calcium from building up and forming calcium kidney stones.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11296431

• Oxalate balance in people with calcium oxalate kidney stones

  This project will find out why some adults make or absorb extra oxalate that increases the chance of calcium oxalate kidney stones.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11232375

• A Probiotic to Prevent Kidney Stones

  This project is developing a new probiotic to help people prevent kidney stones by breaking down a key substance called oxalic acid.

  NIH research Unlocked Labs INC. · Laramie, United States · NIH-11170575

• Understanding how oxalate affects kidney stone formation and immune response

  This study is looking at how eating foods high in oxalate might lead to kidney stones and how it affects kidney health, so if you've had kidney stones before, this research could help find ways to prevent them from coming back.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11163258

• Understanding how a protein affects kidney stones using dogs as a model

  This study is looking at how a protein called uromodulin might affect the risk of kidney stones, especially in dogs, to help us understand how it could lead to better ways to prevent kidney stones in people.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11144694

• Understanding Kidney Stones in Polycystic Kidney Disease

  This project explores how kidney stones might affect kidney function in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11138658

• Investigating how social and dietary factors affect kidney stone risk

  This study looks at how things like where you live and your eating habits can affect your chances of getting kidney stones, especially for Black and Hispanic communities, and it hopes to find ways to suggest better diets to help lower that risk.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11049094

• New methods to predict and prevent kidney stone progression

  This study is working on creating personalized tools to help people with kidney stones understand their risk of getting more stones and find ways to prevent them from getting worse, so they can enjoy better health.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11004024

• Understanding how oxalate levels affect kidney stone formation

  This study is looking at what causes high levels of oxalate in urine, which can lead to kidney stones, and it will explore how things like diet and gut bacteria might help lower those levels for people who are prone to forming stones.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11000774

• Using sound waves to move kidney stones safely

  This study is testing a gentle new way to move kidney stones using sound waves, which could help people pass their stones more easily without surgery and reduce the chances of them coming back.

  NIH research University of Washington · Seattle, United States · NIH-10987043

• Investigating kidney stone disease in patients with ADPKD

  This study is looking at how kidney stones impact people with a genetic condition called autosomal dominant polycystic kidney disease (ADPKD) and aims to find out how these stones might speed up kidney problems, while also checking if antibiotics play a role in this.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10877906

• Improving kidney stone surgery using eye gaze training

  This study is working on a new training tool for kidney stone surgeons that uses eye tracking to help them find and remove stones more easily during surgery, making it better for patients and reducing the chances of needing more surgeries later.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-10870644

• A system to help surgeons locate and remove kidney stones during surgery

  This study is working on a new tool to help surgeons see kidney stones better during surgery, making it easier for them to find and remove the stones, which could lead to fewer repeat surgeries and better results for patients like you.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10833656

• Comparing two strategies to prevent kidney stones

  This study is looking at two ways to help prevent kidney stones in kids and others who are at higher risk: one method uses urine tests to personalize treatment, while the other gives treatment without testing first. The goal is to find out which approach works better and is safer, so we can give clearer advice on how t

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10811584

• Understanding how claudin-2 affects calcium levels and kidney stones

  This study is looking at how a protein called claudin-2 affects calcium levels in the body and could help us find new treatments for people who get kidney stones, especially those with high calcium in their urine.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-10690746

Related topics

Quick answers

How many Kidney Stone clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (13 trials), Egypt (4 trials), France (3 trials), Switzerland (2 trials), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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