Early versus delayed shock wave treatment for leftover kidney stones after percutaneous nephrolithotomy
Optimum Time for Extracorporeal Shock Wave Lithotripsy for Residual Stones After Percutaneous Nephrolithotomy: A Prospective Comparative Randomized Study
NA · Beni-Suef University · NCT07523074
This trial tests whether doing extracorporeal shock wave lithotripsy (ESWL) early or waiting longer after PCNL helps clear leftover kidney stone fragments ≤15 mm with fewer complications.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 476 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Beni-Suef University (other) |
| Locations | 1 site (Banī Suwayf, Beni-Suef Governrate) |
| Trial ID | NCT07523074 on ClinicalTrials.gov |
What this trial studies
This is a prospective, randomized comparison of two timings for ESWL after percutaneous nephrolithotomy in patients with residual renal stones 15 mm or smaller. Eligible adults are randomized to receive ESWL early after PCNL or after a delayed interval, and are followed for stone clearance and procedure-related complications. Key outcomes include stone-free rate, need for additional interventions, and rates of bleeding or infection. The work is conducted at a single center (Beni‑Suef University Hospital) with standard ESWL protocols and predefined safety monitoring.
Who should consider this trial
Good fit: Adults aged 18–70 with single or multiple residual renal stone fragments ≤15 mm after PCNL, normal renal function, and no active urinary tract infection are the intended participants.
Not a fit: Patients with stones >15 mm, obstructed drainage, active sepsis or UTI, bleeding disorders, or on anticoagulant therapy are excluded and unlikely to benefit from the specific findings of this comparison.
Why it matters
Potential benefit: If successful, identifying the best timing could increase stone-free rates and reduce repeat procedures or complications for patients with residual fragments after PCNL.
How similar studies have performed: Observational and retrospective reports suggest early ESWL can improve clearance of residual fragments, but randomized evidence is limited and definitive results are lacking.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-70 years. * Single or multiple residual renal stones ≤15 mm after PCNL. * Normal renal function (serum creatinine \<1.5 mg/dL). * No active UTI. Exclusion Criteria: * Bleeding disorders or anticoagulant therapy. * Obstructed drainage or active sepsis. * Stones \>15 mm or requiring secondary PCNL.
Where this trial is running
Banī Suwayf, Beni-Suef Governrate
- Beni-Suef university hospital — Banī Suwayf, Beni-Suef Governrate, Egypt (RECRUITING)
Study contacts
- Study coordinator: Mahmoud Abdallah Mahmoud, lecturer of urology
- Email: mahmoud.abdalla@med.bsu.edu.eg
- Phone: +2001155361979
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Nephrolithiasis