Clinical trial Recruiting at 1 site Interventional Ages 18 to 70

Early versus delayed shock wave treatment for leftover kidney stones after percutaneous nephrolithotomy

Official title: Optimum Time for Extracorporeal Shock Wave Lithotripsy for Residual Stones After Percutaneous Nephrolithotomy: A Prospective Comparative Randomized Study

Run by Beni-Suef University · NCT07523074 · Data updated 2026-11-12

This trial tests whether doing extracorporeal shock wave lithotripsy (ESWL) early or waiting longer after PCNL helps clear leftover kidney stone fragments ≤15 mm with fewer complications.

Quick facts

Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment476 (estimated)
SponsorBeni-Suef University
Academic / other
Locations1 site (Banī Suwayf, Beni-Suef Governrate)
StatusRecruiting
StartedDecember 2, 2025
Main results expectedOctober 2026
Study endsDecember 2026
Registry record updatedApril 13, 2026
Trial IDNCT07523074 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–70 with single or multiple residual renal stone fragments ≤15 mm after PCNL, normal renal function, and no active urinary tract infection are the intended participants.

Probably not a fit

Patients with stones >15 mm, obstructed drainage, active sepsis or UTI, bleeding disorders, or on anticoagulant therapy are excluded and unlikely to benefit from the specific findings of this comparison.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized comparison of two timings for ESWL after percutaneous nephrolithotomy in patients with residual renal stones 15 mm or smaller. Eligible adults are randomized to receive ESWL early after PCNL or after a delayed interval, and are followed for stone clearance and procedure-related complications. Key outcomes include stone-free rate, need for additional interventions, and rates of bleeding or infection. The work is conducted at a single center (Beni‑Suef University Hospital) with standard ESWL protocols and predefined safety monitoring.

Why it matters

Potential benefit: If successful, identifying the best timing could increase stone-free rates and reduce repeat procedures or complications for patients with residual fragments after PCNL.

How similar studies have gone: Observational and retrospective reports suggest early ESWL can improve clearance of residual fragments, but randomized evidence is limited and definitive results are lacking.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18-70 years.
* Single or multiple residual renal stones ≤15 mm after PCNL.
* Normal renal function (serum creatinine \<1.5 mg/dL).
* No active UTI.

Exclusion Criteria:

* Bleeding disorders or anticoagulant therapy.
* Obstructed drainage or active sepsis.
* Stones \>15 mm or requiring secondary PCNL.

Where it's running

  • Beni-Suef university hospital
    Banī Suwayf, Beni-Suef Governrate, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.