Condition

Kidney Diseases clinical trials and research

• 33Clinical trials
• 19NIH research projects
• 20Countries

Newest Kidney Diseases clinical trials

All recruiting trials (33)

• Improving measures of nutrition, inflammation, kidney function, body composition, and hydration in older adults

  This project will test whether modern blood tests and body-measure techniques give more accurate estimates of nutrition and kidney health for hospitalized people aged 65 and older.

  Recruiting Hvidovre University Hospital · Copenhagen · NCT07501195

• Transformative 2.0 for diabetic kidney disease

  This project will try to see if adults with diabetic kidney disease who take SGLT2 diabetes medicines have different biological patterns in archived kidney tissue than similar people who do not take these medicines.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07444203

• 21-day comprehensive spa care for kidney and urinary conditions

  This program will try a 21-day spa treatment with mineral water baths, drinking cures, exercise and diet for adults 40–70 who have chronic kidney or urinary problems to see if it improves symptoms and kidney health.

  Recruiting Institute of Spa and Balneology, public research institution · Mariánské Lázně, Carlsbad Region · NCT07435844

• Rutgers University Genetics of Kidney Disease

  This project will see if genes are linked to kidney disease risk by collecting health surveys and saliva DNA from people 18 and older in the U.S.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07217535

• Providing tailored produce boxes and nutrition education for Veterans with chronic kidney disease

  This pilot will test whether delivering culturally and medically tailored produce boxes plus nutrition education helps Veterans with stage 3b–4 chronic kidney disease who have food or nutrition insecurity.

  Recruiting VA Eastern Colorado Health Care System · Aurora, Colorado · NCT07194733

• NightWare use for cardiovascular health in women with PTSD-related nightmares

  This study tests whether NightWare can improve heart and kidney health biomarkers in premenopausal women who have PTSD-related nightmares.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07021014

• Amniotic fluid protein test to predict newborn kidney function in pregnancies with fetal kidney abnormalities

  This project will test whether a 98-peptide signature measured in amniotic fluid can predict postnatal kidney function in fetuses with bilateral renal and urinary tract malformations.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06912490

• Long-term zigakibart treatment for adults with IgA nephropathy

  Adults with IgA nephropathy who finished an earlier zigakibart trial will receive ongoing subcutaneous zigakibart every two weeks to see if it stays safe and helps over the long term.

  Recruiting at 26 sites Phase 3 Novartis · Denver, Colorado and 25 other locations · NCT06858319

• NAVIGATE Kidney program to reduce gaps in care for people with advanced CKD

  This project will test whether a community health worker–led NAVIGATE-Kidney program helps adults with advanced CKD (eGFR 15–29) start kidney replacement treatment more safely and avoid early catheter use or premature death.

  Recruiting University of Colorado, Denver · Denver, Colorado and 1 other locations · NCT06810622

• New method for diagnosing acute rejection in kidney transplants

  This study is testing a new way to diagnose acute rejection in kidney transplants by using a special test on urine to help tailor treatments for better recovery.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06801262

• Preventing CMV after receiving a CMV-positive donor kidney using daily antiviral pills or weekly blood monitoring

  This study will test whether taking daily antiviral pills for 200 days or doing weekly blood checks and treating only if the virus appears is better at preventing CMV disease in adults who get a kidney from a CMV-positive donor and are themselves CMV-negative.

  Recruiting at 6 sites Phase 3 University of California, San Francisco · San Francisco, California and 7 other locations · NCT06798909

• Investigating how hyperthyroidism affects kidney transplant outcomes

  This study looks at how changes in thyroid function right after a kidney transplant can affect recovery and overall health for patients.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO · NCT06794203

• Collaborative program to improve kidney care for Black patients at Emory

  This test uses kidney health coaching and clinic decision support to see if it can delay the need for dialysis, central venous catheters, or death in Black adults with advanced chronic kidney disease who receive care through Emory.

  Recruiting at 2 sites Emory University · Atlanta, Georgia and 1 other locations · NCT06693661

• Using vorolanib for treating advanced kidney cancer

  This study is testing if the drug vorolanib can help people with advanced kidney cancer live longer when used as a second treatment option.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT06676527

• Automated carbon dioxide-guided angiography to spare iodinated dye during lower‑leg artery procedures

  This trial tests whether using automated carbon dioxide injections with a contrast‑sparing approach during infrainguinal peripheral vascular interventions reduces serious kidney problems within 90 days in adults with peripheral artery disease and reduced kidney function.

  Recruiting at 8 sites Phase 3 University of Leipzig · Innsbruck and 10 other locations · NCT06656988

• Evaluating telitacicept for treating IgA nephropathy

  This study is testing if a new treatment called telitacicept can help people with IgA nephropathy who are at high risk of their condition getting worse.

  Recruiting Ruijin Hospital · Shanghai · NCT06654596

• Evaluating Enavogliflozin for Heart and Kidney Health in Type 2 Diabetes

  This study is testing if a new diabetes medication called enavogliflozin can improve heart and kidney health in adults with type 2 diabetes compared to other similar medications.

  Recruiting Phase 4 Yonsei University · Seoul · NCT06642623

• Using a digital tool to improve kidney surgery planning

  This study is testing a new digital tool to see if it helps doctors plan kidney surgery better for patients with localized kidney cancer compared to just using regular CT scans.

  Recruiting at 5 sites University Hospital, Ghent · Aalst and 4 other locations · NCT06536439

• Impact of Targeted Physical Activity on Dialysis Patients

  This study is testing if a personalized exercise program can help people on dialysis or with severe kidney disease feel better and improve their health over a year.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT06374537

• Using remote ischemic preconditioning to protect organs during hip surgery

  This study is testing if a special technique called remote ischemic preconditioning can help protect the hearts, kidneys, and brains of older patients during hip surgery.

  Recruiting University of Tartu · Tartu, Tartu · NCT06323018

• Rotigotine in adults with autosomal dominant polycystic kidney disease

  This study tests whether rotigotine, added to standard care, can help people with ADPKD see if their kidney function and related symptoms improve over two years.

  Recruiting at 4 sites Phase 2 University Hospital, Rouen · Amiens and 3 other locations · NCT06291116

• Belatacept vs calcineurin inhibitors and endothelial function in kidney transplant patients

  This study tests whether Belatacept improves blood vessel function compared to calcineurin inhibitors in adults who have had a kidney transplant.

  Recruiting Phase 4 University Hospital, Rouen · Rouen · NCT06291077

• Registry for kidney health during pregnancy

  This study is trying to understand how kidney diseases affect pregnancy and the health of mothers by collecting information from women before, during, and after their pregnancies.

  Recruiting Brugmann University Hospital · Brussels · NCT06067867

• Screening children for kidney disease using urine tests and ultrasounds

  This study is testing if urine tests and ultrasounds can help find kidney disease early in children living in Jiangsu Province and Shanghai.

  Recruiting at 2 sites Children's Hospital of Fudan University · Nantong, Jiangsu and 1 other locations · NCT06018831

• Investigating the impact of being a CF carrier on kidney and pancreatic health

  This study is trying to see if people who carry the cystic fibrosis gene are at a higher risk for kidney and pancreatic diseases compared to others.

  Recruiting University of Iowa · Iowa City, Iowa · NCT05474417

• Research on heart and kidney disease interactions

  This study looks at how heart and kidney problems affect each other to find better treatment options for people with cardiorenal syndrome.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing · NCT05397392

• Observational study of kidney disease patients in China

  This study is trying to learn more about how kidney diseases progress and are managed by following patients in China who have been diagnosed with these conditions.

  Recruiting Emerald Clinical Inc. · Beijing, Beijing Municipality · NCT05036850

• Understanding pediatric hypertension and its effects on the body

  This study looks at how different factors related to blood pressure affect children aged 7-18 who have just been diagnosed with high blood pressure, to see how it impacts their health over two years.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04752293

• Collection and storage of human biological samples for research

  This study is about collecting and storing biological samples from people with different health conditions to help researchers find better ways to prevent, diagnose, and treat diseases.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04706481

• Sparsentan for IgA Nephropathy: safety and activity in adults with incident IgAN and recurrent IgAN after transplant

  This trial tests whether sparsentan can be safely given and help kidney outcomes in adults with immunoglobulin A nephropathy, including people newly diagnosed who haven’t had ACEI/ARB therapy and people with recurrent IgAN after kidney transplant.

  Recruiting at 6 sites Phase 2 University of Leicester · Cambridge, England and 5 other locations · NCT04663204

• National registry for renal angioplasty in patients with resistant hypertension

  This study is setting up a national registry in Denmark to track how well a procedure called renal angioplasty works for patients with high blood pressure caused by narrowed kidney arteries.

  Recruiting at 5 sites University of Aarhus · Aalborg and 4 other locations · NCT02770066

• Data repository for kidney diseases and related conditions

  This study is collecting health information and samples from people with different kidney diseases to see how various factors affect their condition and treatment.

  Recruiting The Rogosin Institute · New York, New York · NCT01802034

• Monitoring molecular changes after kidney transplantation

  This study is testing if checking blood and tissue samples can help doctors spot problems early and improve outcomes for people who have received a kidney transplant.

  Recruiting Odense University Hospital · Odense, DK · NCT01515605

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Chronic Kidney Disease of Unknown Cause in Agricultural Communities

  A wide study to find what causes a serious kidney disease that affects workers in farming areas, by looking at people in high-risk regions.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11526674

• Ubiquitin D as a potential target to help NASH, kidney disease, and liver cancer

  A new approach targets a protein called UBD to help people with fatty liver disease, kidney disease, and liver cancer that can arise from liver disease.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11365217

• Metabolic Boost to Kidney Health in ADPKD

  A Johns Hopkins-led study is exploring how fueling kidney cells with fats and FGF21 signals could slow kidney disease in adults with ADPKD.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11365093

• Graph-based spatial transcriptomics AI methods to understand kidney diseases

  Aims to create AI-powered tools to map where kidney cells are and how they communicate, helping people with chronic kidney disease (CKD) or acute kidney injury (AKI).

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11365041

• How APOL1 gene changes can lead to kidney damage

  Researchers are exploring how APOL1 gene changes found mainly in people of African ancestry can harm kidney cells and contribute to certain non-diabetic chronic kidney diseases.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11252568

• Understanding Ubiquitin D for Liver and Kidney Diseases

  This project looks at a protein called Ubiquitin D to find new ways to help people with liver conditions like NASH and HCC, and also chronic kidney disease.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11176365

• Understanding CKDu in agricultural communities

  This project brings researchers together to find the causes and clues behind chronic kidney disease of unknown cause in farming communities so people affected can get better prevention and care.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11162338

• Understanding Metabolism in Polycystic Kidney Disease

  This research explores how changes in kidney energy use contribute to polycystic kidney disease and how diet or other approaches might help.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11141598

• Using advanced computer methods to understand kidney diseases

  This project is creating new computer tools to better understand how kidney diseases like Chronic Kidney Disease and Acute Kidney Injury develop.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11124641

• Understanding kidney diseases linked to genetic variations in the APOL1 gene

  This study is looking into how certain genetic differences in the APOL1 gene might lead to serious kidney problems that affect many Black patients, and it hopes to find out how these differences cause kidney damage, so we can better understand and treat these conditions.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11030331

• Understanding how genetic changes in nephrin affect kidney diseases

  This study is looking at how certain genetic changes in the nephrin gene might affect kidney diseases like nephrotic syndrome, especially in young people, to help doctors better understand and treat these conditions.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10998554

• A digital platform to help find and enroll patients in clinical trials for rare kidney diseases

  This study is working on a new mobile app called Arkana Connect™ to help doctors find and enroll patients with rare kidney diseases in clinical trials more easily, so that those patients can get the best possible treatment options.

  NIH research Nephropathology Associates · Little Rock, United States · NIH-10930152

• Training future scientists in computational methods for diabetes and digestive diseases

  This program is all about helping future scientists and doctors learn how to use computer skills to better understand and research diabetes, digestive issues, and kidney diseases, so they can make new discoveries that improve health.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10897098

• Investigating chronic kidney disease in agricultural communities

  This study is looking into chronic kidney disease that affects farming communities, and it aims to find out what causes it and how it develops, so if you're a patient, your health information and samples could really help us learn more about this condition.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-10890138

• Investigating how metabolic changes and FGF21 signaling affect kidney health in polycystic kidney disease.

  This study is looking at how a special diet that helps your body burn fat might improve kidney health for people with autosomal dominant polycystic kidney disease (ADPKD) and whether it can slow down the disease's progress.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10861027

• New treatments for kidney diseases that cause protein loss.

  This study is looking at a new treatment that could help improve kidney function by focusing on a specific pathway important for kidney cells, especially the ones that filter blood, to reduce protein loss in urine, which is a common issue for people with kidney problems.

  NIH research Boston Medical Center · Boston, United States · NIH-10842285

• Improving kidney health in patients with chronic kidney disease through a systems biology approach.

  This study is looking at how low oxygen levels affect kidney cells in people with chronic kidney disease, and it aims to create a helpful scoring system to better understand how these changes relate to patient outcomes, which could lead to improved treatments for those living with this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10755642

• Creating a comprehensive data resource for kidney and urinary tract health

  This study is creating a helpful online resource that gathers and organizes important information about kidney and urinary tract development and diseases, making it easier for researchers to find and understand data to improve our health.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10708942

• A smart home test for detecting kidney disease flares in autoimmune patients

  This study is working on a simple at-home test that helps people with lupus nephritis check their kidney health using urine samples, so they can get quick results on their smartphones and make faster decisions about their treatment.

  NIH research University of Houston · Houston, United States · NIH-10555290

Related topics

Quick answers

How many Kidney Diseases clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (12 trials), China (5 trials), Denmark (3 trials), France (3 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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