Condition

Kidney Stones clinical trials and research

• 19Clinical trials
• 7NIH research projects
• 6Countries

Newest Kidney Stones clinical trials

All recruiting trials (19)

• Modified Mini-PCNL vs Standard PCNL for Complex Kidney Stones

  This study tests whether a smaller 20 Fr access in modified mini-PCNL can match the stone-clearing success of the standard 24 Fr PCNL in adults with complex kidney stones.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT07697677

• Aspirating vs non-aspirating ureteral access sheath in RIRS for kidney stones

  This trial tests whether using an aspirating ureteral access sheath during retrograde intrarenal surgery improves stone clearance and reduces complications compared with a non-aspirating sheath in adults with small kidney stones.

  Recruiting Hitit University · Çorum, Çorum · NCT07568990

• Suction to collapse the kidney's collecting system after RIRS (retrograde intrarenal surgery)

  This trial will test whether actively suctioning the kidney's collecting system at the end of RIRS reduces early postoperative pain and infections for adults having kidney stone removal.

  Recruiting Kangdong Sacred Heart Hospital · Gandong-gu, Outside U.S./Canada · NCT07535281

• Compare two suction ureteroscope devices for kidney stones (FANS vs CVAC)

  This study tests whether two new suction-enabled ureteroscopes (FANS and CVAC) lead to better stone clearance for adults with small to medium kidney stones compared to each other.

  Recruiting Ohio State University · Columbus, Ohio · NCT07514351

• Negative-pressure suction during flexible ureteroscopy to reduce fluid absorption and infections

  This test will see if using a negative-pressure suction sheath during retrograde intrarenal surgery for adults with kidney stones reduces how much irrigation fluid their bodies absorb and lowers the risk of postoperative infections.

  Recruiting Lanzhou University Second Hospital · Lanzhou, Gansu · NCT07492147

• Outcomes and costs with the HugeMed 6.3 Fr flexible ureteroscope

  This trial will test whether the HugeMed 6.3 Fr flexible ureteroscope gives similar stone-free results while lowering costs compared with traditional flexible ureteroscopes in adults having RIRS for stones up to 2.5 cm.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07296835

• MODULITH SLX-F2 shockwave treatment with StorM-Track versus standard targeting for kidney stones

  This will test if using StorM-Track real-time stone tracking with the MODULITH SLX-F2 shockwave machine helps adults with 6–15 mm kidney stones become stone-free more often than standard shockwave treatment.

  Recruiting Storz Medical AG · Stockholm · NCT07272720

• Preventing calcium oxalate kidney stones

  This test compares giving empiric preventive treatment right after kidney stone surgery to using 24-hour urine tests to guide treatment for people with calcium oxalate stones.

  Recruiting Phase 4 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07225764

• Stone clearance with steerable ureteroscopic evacuation compared with other methods

  This study tests whether the CVAC/SURE approach helps clear kidney stones more effectively than standard renal-stone interventions in patients needing ureteroscopy or PCNL.

  Recruiting at 10 sites Calyxo, Inc. · Miami, Florida and 9 other locations · NCT07155005

• Steerable Ureteroscopic Renal Evacuation (SURE) with CVAC vs standard ureteroscopy

  This trial tests whether the SURE system with CVAC can improve outcomes compared with standard ureteroscopy with laser lithotripsy for kidney stones in adult patients.

  Recruiting at 6 sites Calyxo, Inc. · Birmingham, Alabama and 5 other locations · NCT07101809

• Empagliflozin for people with calcium kidney stones

  This trial will test whether taking empagliflozin for four weeks changes urine chemicals linked to stone formation in adults who've had calcium kidney stones.

  Recruiting Early Phase 1 University of Chicago · Chicago, Illinois · NCT07055282

• Comparing robotic and manual methods for treating kidney stones

  This study is testing whether a robotic system works better than traditional manual methods for treating kidney stones to see which approach is safer and more effective for adults.

  Recruiting American University of Beirut Medical Center · Beirut · NCT06996587

• Investigating oxalate production in patients with calcium oxalate kidney stones

  This study is testing if people with calcium oxalate kidney stones produce more oxalate in their bodies than healthy individuals by following a special diet and taking certain supplements.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06989320

• Comparing steerable and conventional access sheaths for treating small kidney stones

  This study is testing a new flexible tool for removing small kidney stones to see if it works better and is safer than the standard method.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06898216

• Using laughter yoga to reduce surgical fear and anxiety before ureteroscopy

  This study is testing if laughter yoga can help reduce fear and anxiety in patients getting ready for ureteroscopy surgery.

  Recruiting Kocaeli University · Samsun, Samsun · NCT06758284

• Comparing two laser systems for breaking up kidney stones

  This study is testing whether a new type of laser for breaking up kidney stones works as well and as quickly as a current laser option during a minimally invasive procedure.

  Recruiting University of California, San Diego · San Diego, California · NCT06721975

• Vacuum-assisted vs conventional ureteral access sheath in modern kidney stone surgery

  This trial tests whether vacuum-assisted ureteral access sheaths improve stone removal and safety in retrograde intrarenal surgery for adults with kidney stones.

  Recruiting Namik Kemal University · Tekirdağ, Turkey · NCT06684756

• Fecal Microbiota Transplantation for Kidney Stone Patients

  This study is testing if a new treatment using healthy gut bacteria can help people with recurring kidney stones caused by high levels of calcium and oxalate in their urine.

  Recruiting Early Phase 1 Intermountain Health Care, Inc. · Park City, Utah · NCT05516472

• Understanding how dietary oxalate affects kidney stones and immunity

  This study tests how different amounts of oxalate in food affect kidney stones and the immune system in both healthy people and those with kidney stones.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05417568

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Break Wave therapy to break big kidney stones safely

  A noninvasive therapy called Break Wave uses low-frequency ultrasound to fragment large kidney stones (10–20 mm) without surgery.

  NIH research Sonomotion, INC. · Emerald Hills, United States · NIH-11342227

• A new flexible endoscope that quickly removes large kidney stones

  This study is testing a new flexible tool that can quickly change from a camera used to look inside the body into a suction device that helps remove big kidney stones, making it easier and faster for patients to get treatment without needing major surgery.

  NIH research Endotheia, INC. · Nashville, United States · NIH-11110725

• A new method to break large kidney stones using sound waves

  This study is testing a new, gentle treatment called burst wave lithotripsy that uses sound waves to break up larger kidney stones (10-20 mm) without surgery, aiming to make the process safer and more effective for people dealing with these stones.

  NIH research Sonomotion, INC. · Emerald Hills, United States · NIH-11066949

• Using gold-based materials to break down kidney stones

  This study is exploring a new way to treat kidney stones using special gold materials that can help break them down safely, so patients can have a less invasive and more effective option than current treatments.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10985150

• A new flexible endoscope for quickly removing large kidney stones

  This study is testing a new type of flexible tool that can quickly change from a camera used to look inside the body into a suction device that helps remove large kidney stones, making it easier and faster for patients to get treatment without needing major surgery.

  NIH research Endotheia, INC. · Nashville, United States · NIH-10896987

• Effectiveness of medications to prevent kidney stones

  This study is looking at how well medications like thiazide diuretics and allopurinol can help people who have had kidney stones avoid getting them again, focusing on real-life results that matter to you, like fewer painful episodes and trips to the emergency room.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10833141

• Factors from a gut bacterium that affect kidney stone formation

  This study is looking at how a friendly gut bacterium can help lower the amount of oxalate in urine, which can lead to kidney stones, and it’s for anyone who wants to find new ways to prevent these painful stones from forming.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10661844

Related topics

Quick answers

How many Kidney Stones clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (10 trials), Turkey (Türkiye) (3 trials), China (3 trials), South Korea (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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