Understanding how calcium signaling affects kidney stone formation
Official title: Calcium signaling mechanism in proximal tubule underlying calcium nephrolithiasis
Funded at U.s. Dept/vets Affairs Medical Center · NIH-11050052 · Data updated 2026-11-12
This study is looking at how calcium levels and acidity in the kidneys affect the formation of calcium-based kidney stones, with the hope of finding new ways to help people prevent these stones from forming.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. Dept/vets Affairs Medical Center NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01BX006849-01 |
| Project ID | NIH-11050052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of calcium nephrolithiasis or those at high risk for developing kidney stones.
✕Less likely to help
Patients who do not have a history of kidney stones or related urinary tract issues may not benefit from this research.
What this research studies
This research investigates the mechanisms behind calcium nephrolithiasis, a condition where kidney stones form primarily from calcium compounds. It focuses on how calcium levels and pH in the proximal tubule of the kidneys influence the crystallization of calcium phosphate stones. By studying animal models, the research aims to identify the role of specific calcium channels in this process, which could lead to new prevention strategies for kidney stones. Patients may benefit from insights that could inform dietary or medical interventions to reduce stone formation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney stones, improving patient quality of life.
How similar studies have gone: Previous research has shown promising results in understanding calcium signaling in kidney stone formation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
U.s. Dept/vets Affairs Medical Center
Washington, United States Active
Researchers
- Principal investigator: Bandyopadhyay, Bidhan Chandra — U.s. Dept/vets Affairs Medical Center
- Study coordinator: Bandyopadhyay, Bidhan Chandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.