Shock wave treatment versus flexible ureteroscopy for a single 1–2 cm kidney stone
Comparison of Outcomes of Extracorporeal Shock Wave Lithotripsy Versus Retrograde Intrarenal Surgery in the Management of Renal Calculi Measuring 1 to 2 Centimeters
NA · Ziauddin Hospital · NCT07261995
This research will test whether shock waves from outside the body (ESWL) or a flexible scope with laser (RIRS) works better for adults 18–65 who have a single 1–2 cm kidney stone.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 98 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ziauddin Hospital (other) |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT07261995 on ClinicalTrials.gov |
What this trial studies
This single-center comparison in Karachi enrolls adults aged 18–65 with a single renal calculus measuring 1–2 cm confirmed on imaging. Treatment is either extracorporeal shock wave lithotripsy (ESWL) as a day-care outpatient procedure or retrograde intrarenal surgery (RIRS) under general anesthesia using a flexible scope and laser, with choice made by the urologist and patient. Participants receive standard pre- and post-procedure care and are followed to monitor stone clearance, complications, and need for additional procedures. The design reflects real-world practice in Pakistan where both techniques are commonly used.
Who should consider this trial
Good fit: Adults 18–65 with a single renal stone measuring 1–2 cm on imaging and without active infection, severe kidney dysfunction, anatomical abnormalities, pregnancy, morbid obesity, bleeding disorders, or a solitary kidney are suitable candidates.
Not a fit: People with multiple or bilateral stones, anatomical kidney anomalies, active urinary infection, pregnancy, uncontrolled bleeding risk, severe chronic kidney disease, morbid obesity, or a solitary kidney are excluded and unlikely to benefit from this comparison.
Why it matters
Potential benefit: If successful, the comparison could show which approach clears 1–2 cm stones with fewer repeat procedures, complications, or hospital visits and help guide treatment choices.
How similar studies have performed: Previous clinical reports are mixed but generally show RIRS often achieves higher stone-free rates for 1–2 cm stones while ESWL is less invasive though it may require repeat treatments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged between 18 and 65 years. * Patients diagnosed with a single renal calculus measuring between 1 cm and 2 cm, confirmed on imaging (ultrasound or non-contrast CT KUB). Exclusion Criteria: * Presence of multiple renal stones or bilateral renal stones. * Patients with anatomical abnormalities such as horseshoe kidney, ureteropelvic junction obstruction, or calyceal diverticulum based on medical history or radiological findings. * Active urinary tract infection at the time of intervention. * Pregnant women. * Patients with bleeding disorders or on anticoagulation therapy that cannot be safely stopped. * Patients with chronic kidney disease (eGFR \< 30 mL/min/1.73 m²). * Patients with morbid obesity (BMI \> 40 kg/m²). * Patients with solitary kidney.
Where this trial is running
Karachi, Sindh
- Ziauddin Hospital — Karachi, Sindh, Pakistan (RECRUITING)
Study contacts
- Principal investigator: Muhammad Waqas Arshad — Ziauddin Universty
- Study coordinator: Muhammad Waqas Arshad Arshad
- Email: waqasarshad617@gmail.com
- Phone: +9221358629379
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Nephrolithiasis, Renal Calculi, Kidney stones, Urolithiasis, Extracorporeal shock wave lithotripsy, Retrograde intrarenal surgery