Predicting kidney stone recurrence and complications using precision medicine
Official title: Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach
Run by Centre Hospitalier Universitaire, Amiens · NCT05237063 · Data updated 2026-11-12
This study is trying to find out what causes kidney stones to come back so that we can help people avoid getting them again.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | January 13, 2021 |
| Main results expected | February 2026 |
| Study ends | February 2031 |
| Registry record updated | February 8, 2023 |
| Trial ID | NCT05237063 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older who have experienced at least one renal colic attack.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to identify the clinical, biological, genetic, molecular, and environmental factors that predict the recurrence of kidney stones, a common condition affecting a significant portion of the population. Participants will provide blood and urine samples during routine follow-up visits over a period of five years. The samples will be analyzed to uncover determinants that could help in managing and preventing future episodes of nephrolithiasis. The study is designed to enhance understanding of kidney stone formation and recurrence.
Why it matters
Potential benefit: If successful, this study could lead to personalized prevention strategies for patients at risk of recurrent kidney stones.
How similar studies have gone: While there have been studies on kidney stones, this precision medicine approach focusing on a comprehensive set of predictive factors is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥18 years old), male or female , * Persons able to understand and object to the information provided (at the discretion of the investigator) * Patient affiliated to social security * Patient agreeing to sign the informed consent form * patient having presented at least one renal colic attack before inclusion Exclusion Criteria: * Pregnant or breastfeeding woman. * Persons deprived of liberty, * Adults under legal protection guardianship, or curators or unable to express their consent. * Patient refusing to participate in the study * Patient in an emergency situation
Where it's running
-
CHU Amiens Nord
Amiens, France Recruiting
Study contacts
- Study coordinator: Dominique Eladari, Pr
- Email: dominique.eladari@inserm.fr
- Phone: 06 13 03 99 01
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Observation vs Upfront Surgery for Asymptomatic Kidney Stones in Children and Adults
This trial tests whether watching asymptomatic kidney stones or performing upfront surgery is better for reducing life disruption in patients aged 6 and older.
-
Ho:YAG versus thulium fiber laser for mini-PCNL with the ClearPetra suction sheath
This trial will see if the Ho:YAG or thulium fiber laser clears kidney stones better during mini-PCNL with the ClearPetra suction sheath in adults with stones larger than 15 mm.
-
Empagliflozin and personalized diet for preventing calcium kidney stones
This study tests whether the diabetes drug empagliflozin plus tailored dietary counseling can reduce recurrent calcium kidney stones in adults.
-
LithoVue Elite ureteroscope with real‑time kidney pressure monitoring during flexible ureteroscopy.
This test will see if showing surgeons real‑time kidney pressure readings during flexible ureteroscopy changes how they operate and affects outcomes for adults having ureteroscopy for kidney or proximal ureter stones larger than 2 cm.
-
Investigating how the gut absorbs oxalate in kidney stone patients
This study is trying to see if people with kidney stones absorb more oxalate from their diet than healthy individuals, which might lead to more oxalate in their urine.
-
Using gut bacteria to reduce urinary oxalate in kidney stone patients
This study is testing if introducing a specific gut bacteria can help adults with calcium oxalate kidney stones lower the amount of oxalate in their urine.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.