Clinical Trial Readiness for Multiple System Atrophy
Official title: Clinical Trial Readiness for Multiple System Atrophy - Resubmission - 1
Funded at New York University School of Medicine · NIH-11392980 · Data updated 2026-11-12
A multi-center study to help people with multiple system atrophy by creating better clinical and biological measures to use in future drug trials.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 15, 2022 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,147,774 |
| NIH project number | 5U01NS122419-04 |
| Project ID | NIH-11392980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older diagnosed with multiple system atrophy.
✕Less likely to help
Participants without MSA or those unwilling to undergo long-term follow-up may not benefit.
What this research studies
Researchers at NYU are building and testing new ways to measure how MSA progresses so future therapies can be tested more quickly and accurately. The project will follow 100 adults with MSA over a year to see which clinical scales and biomarkers best reflect changes in the disease. This work aims to speed up the development of treatments by providing robust tools that regulators and doctors can rely on in upcoming trials.
Why it matters
Potential benefit: If successful, patients with MSA could benefit from faster, more reliable clinical trials and better monitoring of disease progression.
How similar studies have gone: There is a need for more sensitive outcome measures beyond current scales like UMSARS; this study seeks to improve that toolkit.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Kaufmann, Horacio — New York University School of Medicine
- Study coordinator: Kaufmann, Horacio
Related research
Other NIH-funded projects on the same topics.
-
Integrated MRI biomarkers to diagnose and monitor multiple system atrophy
This project will help doctors use MRI markers to better diagnose multiple system atrophy and track how the disease progresses.
-
Single-cell brain profiling to map MSA cell changes
Researchers will map gene activity in individual brain cells from people who had multiple system atrophy to understand how the disease affects cells in key brain regions.
-
Investigating how inflammation caused by alpha-synuclein affects multiple system atrophy
This study is looking at how inflammation affects multiple system atrophy (MSA) and aims to understand how the immune system might play a role in the disease, with the hope of finding new ways to help people with MSA.
-
Understanding brain inflammation in multiple system atrophy
This research explores how a specific immune signal, interferon-gamma, contributes to brain damage in multiple system atrophy.
-
Single-cell gene map of brains from people with multiple system atrophy
This project reads gene activity in individual brain cells from people with multiple system atrophy to find cell-specific changes linked to the disease.
-
Identifying biomarkers for multiple system atrophy using gene expression analysis
This study is looking at how multiple system atrophy (MSA) affects brain cells by examining changes in their genes, and it aims to find new ways to diagnose and treat the condition, with opportunities for patients to help by sharing samples.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.