Understanding pain and autonomic symptoms in Parkinson's disease and atypical parkinsonisms
Official title: Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms: Identification of Predictive Patterns of Rehabilitation Outcome and Evaluation of the Impact on Quality of Life
Run by Istituti Clinici Scientifici Maugeri SpA · NCT05748028 · Data updated 2026-11-12
This study looks at how pain and other symptoms affect people with Parkinson's disease and multiple system atrophy to see if rehabilitation can help improve their quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 280 (estimated) |
| Sponsor | Istituti Clinici Scientifici Maugeri SpA Academic / other |
| Locations | 9 sites (Telese Terme, Benevento and 8 other locations) |
| Status | Recruiting |
| Started | June 15, 2019 |
| Main results expected | September 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | April 17, 2026 |
| Trial ID | NCT05748028 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with Parkinson's disease or multiple system atrophy who meet specific clinical criteria.
✕Probably not a fit
Patients with vascular or pharmacological parkinsonism, diabetes mellitus, or those on potentially neurotoxic drugs may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the prevalence and characteristics of pain and autonomic symptoms in patients diagnosed with Parkinson's disease (PD) and multiple system atrophy (MSA). It will evaluate the effects of rehabilitation on these symptoms and assess their impact on the quality of life of the participants. Patients will undergo neurological examinations, participate in rehabilitation programs, and complete clinical scales to gather comprehensive data. The study will compare the experiences of patients with PD and MSA to better understand their unique challenges and treatment responses.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for pain and autonomic symptoms in patients with Parkinson's disease and MSA, enhancing their quality of life.
How similar studies have gone: While there is growing interest in the non-motor symptoms of Parkinson's disease, this specific approach to evaluating pain and autonomic symptoms in relation to rehabilitation is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of Parkinson's Disease or Multiple System Atrophy according to current international criteria (Gilman S et al, 2008; Postuma RB et al. 2015). * Mini-Mental State Examination score at least 10 Exclusion Criteria: * vascular or pharmacological parkinsonism * diabetes mellitus * hepatic or renal dysmetabolism, * hypothyroidism or hyperthyroidism * assumption of potentially neurotoxic drugs
Where it's running
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ICS Maugeri - IRCCS of Telese Terme
Telese Terme, Benevento, Italy Recruiting -
ICS Maugeri - Lumezzane
Lumezzane, Brescia, Italy Recruiting -
ICS Maugeri - Castelgoffredo
Castel Goffredo, Mantova, Italy Recruiting -
ICS Maugeri - Mistretta
Mistretta, Messina, Italy Recruiting -
ICS Maugeri - Veruno
Veruno, Novara, Italy Recruiting -
ICS Maugeri - Montescano
Montescano, Pavia, Italy Recruiting
Show 3 more locations
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ICS Maugeri - Milano
Milan, Italy Recruiting -
ICS Maugeri - Pavia Boezio
Pavia, Italy Recruiting -
ICS Maugeri - Pavia
Pavia, Italy Recruiting
Study contacts
- Principal investigator: Maria Nolano, MD, PhD — Isituti Clinici Scientifici Maugeri SpA SB - IRCCS of Telese Terme
- Study coordinator: Maria Nolano, MD, PhD
- Email: maria.nolano@icsmaugeri.it
- Phone: +390824909257
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.