Investigating brain changes in multiple system atrophy
Single Cell Transcriptomic Profiling of Multiple System Atrophy Brain
This study is looking at brain tissue from people with multiple system atrophy (MSA) to learn more about how the disease affects different brain cells, especially those that support nerve health, which could help us find new ways to treat MSA in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10801665 on NIH RePORTER |
What this research studies
This research focuses on understanding multiple system atrophy (MSA), a rare neurodegenerative disease, by analyzing brain tissue from affected patients. Using advanced techniques like single nucleus RNA sequencing, the study aims to identify specific changes in different types of brain cells, particularly oligodendrocytes, which are crucial for neuronal health. By examining tissue from various brain regions, the research seeks to uncover the mechanisms behind the disease and how it affects brain function. This could lead to better insights into the progression of MSA and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple system atrophy, particularly those with either MSA-P or MSA-C subtypes.
Not a fit: Patients with other neurodegenerative diseases or those not diagnosed with multiple system atrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with multiple system atrophy.
How similar studies have performed: While research on neurodegenerative diseases is ongoing, this specific approach using single nucleus RNA sequencing in MSA is relatively novel and has not been extensively tested.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Kang, Un Jung — New York University School of Medicine
- Study coordinator: Kang, Un Jung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.