Understanding brain inflammation in multiple system atrophy
Interferon-gamma mediates neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy (MSA)
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11144952
This research explores how a specific immune signal, interferon-gamma, contributes to brain damage in multiple system atrophy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11144952 on ClinicalTrials.gov |
What this research studies
Multiple system atrophy (MSA) is a serious brain disease where a protein called alpha-synuclein builds up, leading to inflammation and damage to nerve coverings. We know that immune cells called T cells are involved, releasing a signal called interferon-gamma. This project aims to understand exactly how interferon-gamma causes inflammation and nerve damage in MSA. By studying its role, we hope to uncover new ways to protect the brain from this progressive disease.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals living with multiple system atrophy, as it seeks to understand the underlying disease mechanisms.
Not a fit: Patients currently seeking direct treatment or clinical trial participation will not find immediate benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could identify new targets for treatments that slow down or stop the progression of multiple system atrophy by reducing harmful brain inflammation.
How similar studies have performed: Previous research has shown that inflammation and T cells are present in the brains of MSA patients, and preliminary results from this team suggest interferon-gamma plays a key role.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORBIN-STEIN, NICOLE — YALE UNIVERSITY
- Study coordinator: CORBIN-STEIN, NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease