Investigating cholesterol metabolism in multiple system atrophy
Abnormalities of cholesterol metabolism in multiple system atrophy
This study is looking at how cholesterol levels change in people with multiple system atrophy (MSA) to see if it can help us find new ways to treat this condition, and we’d love for patients to help by sharing some samples.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10792884 on NIH RePORTER |
What this research studies
This research focuses on understanding how cholesterol metabolism is affected in patients with multiple system atrophy (MSA), a neurodegenerative condition that leads to coordination and movement difficulties. The study aims to explore the relationship between cholesterol levels and Coenzyme Q, a vital molecule for cell function, particularly in the brain. By examining these metabolic pathways, researchers hope to uncover potential therapeutic targets that could lead to new treatments for MSA. Patients may be involved in providing biological samples to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with multiple system atrophy who are experiencing symptoms related to the condition.
Not a fit: Patients with other neurodegenerative diseases or those without a diagnosis of multiple system atrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that modify the progression of multiple system atrophy.
How similar studies have performed: While the specific focus on cholesterol metabolism in MSA is novel, similar research in other neurodegenerative diseases has shown promising results in understanding metabolic pathways.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Quinzii, Catarina M. — Columbia University Health Sciences
- Study coordinator: Quinzii, Catarina M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.