Using a non-invasive device to help manage symptoms in people with Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of the CUE1 device, which delivers pulsing cueing and vibrotactile stimulation, to alleviate both motor and non-motor symptoms in individuals with Parkinson's disease and related disorders. Participants will wear the device on their sternum or forearm for a duration of 9 weeks to assess its feasibility, safety, tolerability, and effectiveness. The study aims to provide insights into how this non-invasive approach can improve the quality of life for those affected by Parkinson's disease. Previous small case studies have indicated potential benefits of this device.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults over 18 years old
* Clinical diagnosis of idiopathic PD and related disorders including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and vascular Parkinsonism (VaP) as well as atypical dystonias and tremor disorders and Orthostatic Tremor (OT)
* willing to participate and written consent provided after read the participant information sheet.

Exclusion Criteria:

Individuals with:

* other neurological disorders excluding idiopathic PD, related disorders such PSP, MSA, CBD, and VaP as well as atypical dystonias and tremor disorders, affecting movement, balance and gait
* metabolic or autoimmune disorders affecting movement, balance and gait
* acute orthopaedic disorders influencing balance control and gait
* audiovestibular disorders including severe hearing loss
* visual disturbances, poor eyesight
* not able to provide written consent form to participate
* clinical diagnosis of cognitive impairment including dementia or Alzheimer's.
* Mental impairments (illusions, hallucinations, impulse control disorders) (self-reported)

Technical contraindications related to CUE1 device:

* implanted metallic or electronic devices usage
* hypersensitivity to vibrotactile stimulation
* skin conditions and/or open wound in the area of where the device will be positioned (e.g., sternum) if taking medicines for PD or related disorder, then on stable dose of treatment for the last three months.

Where it's running

• Queen Mary University of London
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Cristina Simonet, PhD
• Email: c.simonet@qmul.ac.uk
• Phone: 020 7882 3543

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.