Using AI to find facial and speech signs of Parkinson's and related disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study records participants' facial expressions on video and speech audio to generate datasets for machine-learning analysis. Participants include people with Parkinson's disease across early and later stages, patients with progressive supranuclear palsy or multiple system atrophy, and healthy controls. AI models will be trained to identify patterns in facial and vocal features that may serve as digital biomarkers for diagnosis and differentiation. All data collection is performed in person at a single center with informed consent and standard clinical diagnostic criteria used for group assignment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Inclusion Criteria for Parkinson's Disease (PD) Group: (1) Diagnostic Criteria: Meet the diagnostic criteria for Parkinson's disease established by the Movement Disorder Society (MDS) in 2015. (2) Age Range: 18-75 years old. (3) Disease Severity: Early-stage PD: Hoehn-Yahr score ≤ 2.5 points. Mid-to-late-stage PD: Hoehn-Yahr score 2.5-5 points. (4) Consent for Data Collection: Willing to undergo facial expression video and speech audio recording. (5) Informed Consent: Signed informed consent form.
2. Inclusion Criteria for Parkinson's Plus Syndromes (MSA-P, PSP) Group: (1) Age Range: 18-75 years old. (2) Diagnostic Criteria: MSA patients must meet the diagnostic criteria established by the \[Chinese Expert Consensus on the Diagnosis of Multiple System Atrophy, 2017\]. PSP patients must meet the diagnostic criteria established by the \[Chinese Clinical Diagnostic Criteria for Progressive Supranuclear Palsy, 2016 Edition\]. (3) Consent for Data Collection: Willing to undergo facial expression video and speech audio recording. (4) Informed Consent: Signed informed consent form.

Exclusion Criteria:

1. History of cerebrovascular disease, head trauma, hydrocephalus, brain tumors, or intracranial surgery.
2. Presence of metal implants, cardiac pacemakers, or other metallic foreign bodies (applies to PD patients).
3. Severe dyskinesia in PD patients that would compromise cooperation with video/audio recording.
4. Mini-Mental State Examination (MMSE) score ≤ 24 points.

Where it's running

• 首都医科大学附属北京天坛医院
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Lingyan Ma, M.D.
• Email: Jennifer_MLY@163.com
• Phone: +8613520873987

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Longitudinal registry of people with multiple system atrophy in China

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• Implanting nerve tissue into the brain for Parkinson's and Multiple System Atrophy

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• Evaluating a new PET imaging agent for brain conditions

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  Recruiting Early Phase 1 Massachusetts General Hospital · Charlestown, Massachusetts · NCT06098612

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.