Identifying biomarkers for multiple system atrophy using gene expression analysis
A transcriptomics-based approach to identify quantitative biomarkers for multiple system atrophy
This study is looking at how multiple system atrophy (MSA) affects brain cells by examining changes in their genes, and it aims to find new ways to diagnose and treat the condition, with opportunities for patients to help by sharing samples.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-10998160 on NIH RePORTER |
What this research studies
This research aims to uncover changes in gene expression related to multiple system atrophy (MSA), a severe neurodegenerative disorder. By utilizing RNA sequencing on human-derived neurons affected by MSA, the researchers will explore how the disease alters neuronal function and identify potential biomarkers that could aid in diagnosis and treatment. The study will also involve validating these findings using brain tissue samples from MSA patients and conducting experiments in a mouse model to further understand the disease mechanisms. Patients may have the opportunity to contribute to this research by providing biological samples.
Who could benefit from this research
Good fit: Ideal candidates for participation would be individuals diagnosed with multiple system atrophy or those at risk for developing the condition.
Not a fit: Patients with other neurodegenerative disorders unrelated to multiple system atrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new diagnostic tools and therapeutic targets for multiple system atrophy.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for other neurodegenerative diseases, suggesting that this approach may yield valuable insights for MSA as well.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Khedmatgozar, Chase Reza — Colorado State University
- Study coordinator: Khedmatgozar, Chase Reza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.