Natural history of atypical parkinsonian syndromes: a multi-center observation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, multi-center study aimed at detailing how motor and non-motor symptoms progress in atypical parkinsonian syndromes. Researchers will document clinical features and imaging patterns to create a comprehensive assessment framework. The project builds clinical and biological databases to identify biomarkers that may predict disease trajectory. No experimental treatments are given; data collection is purely observational. Participants are followed over time to characterize the natural history of these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) .
2. DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) .
3. PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years .
4. CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb).

Exclusion Criteria:

1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure .
2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .

Where it's running

• Changshu Hospital Affiliated to Nanjing University of Chinese Medicine
  Changshu, Jiangsu, China Recruiting
• Jiangsu Province (Suqian) Hospital
  Suqian, Jiangsu, China Recruiting
• The Forth Affiliated Hospital of Soochow University
  Suzhou, Jiangsu, China Recruiting
• The Second Affiliated Hospital of Soochow University
  Suzhou, Jiangsu, China Recruiting
• Yancheng Third People's Hospital
  Yancheng, Jiangsu, China Recruiting
• The Forth People's Hospital of Zhenjiang
  Zhenjiang, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Jinru Zhang, PhD. MD.
• Email: zhangjinruruby@126.com
• Phone: +8615850210657

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.