Tributyrin for PSP: a virtual, early-phase study
Official title: Tributyrin for PSP: Phase 1b Virtual Trial - Feasibility Study
Run by University of Michigan · NCT07863180 · Data updated 2026-11-12
This study tests whether tributyrin is safe and tolerable in people with Progressive Supranuclear Palsy who are 45 or older, using virtual visits.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 45 Years and up |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University of Michigan Academic / other |
| Locations | 1 site (Ann Arbor, Michigan) |
| Status | Recruiting |
| Started | October 1, 2026 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07863180 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 45+ with PSP-Richardson syndrome who have internet access and an available caregiver.
✕Probably not a fit
Participants with significant uncontrolled GI disease, certain metabolic issues, or pregnancy will be unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a Phase 1/2 sub-study evaluating tributyrin versus placebo in PSP. The trial uses virtual visits to assess safety, tolerability, and feasibility of a remote testing workflow. Participants must have PSP-Richardson syndrome, access to the internet with a caregiver, and meet safety criteria. The study is conducted as part of a larger program and leverages collaboration between a private sponsor and a foundation.
Why it matters
Potential benefit: If successful, tributyrin could be studied further as a potential approach to support PSP management.
How similar studies have gone: Prior work in related fatty acid supplements and microbiome approaches has shown safety signals in comparable populations, but this trial is a novel remote-format sub-study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or Female, age 45 years and over. * Diagnosis of PSP-Richardson syndrome (RS) based on Movement Disorder Society (MDS) Criteria, including 1. Vertical supranuclear gaze palsy. 2. Repeated unprovoked falls OR tendency to fall on the pull test within 3 years. * Access to the internet and webcam for virtual visits. * Presence of a caregiver. Exclusion Criteria: * Recent history of significant, uncontrolled GI disease such as Gastroesophageal reflux disease, colorectal cancer. * Significant metabolic or uncontrolled medical comorbidity. * Regular use of typical anti-cholinergic drugs. * Women of child-bearing potential, or who are pregnant and/or nursing. * Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory. * Any other condition or criterion that, in the opinion of the investigators, would preclude safe and meaningful participation in the study.
Where it's running
-
Domino's Farms
Ann Arbor, Michigan, United States Recruiting
Study contacts
- Principal investigator: Prabesh Kanel, PhD — University of Michigan
- Study coordinator: Nathan Alexander
- Email: natealex@med.umich.edu
- Phone: 734-998-8422
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.