Condition

Progressive Supranuclear Palsy clinical trials and research

• 19Clinical trials
• 9NIH research projects
• 17Countries

Newest Progressive Supranuclear Palsy clinical trials

All recruiting trials (19)

• Wellness program for PSP and CBD: a virtual multimodal lifestyle approach

  This study tests a virtual 8-week program combining chair yoga, voice strengthening, and peer support to see if it improves emotional wellbeing and quality of life for adults with PSP or CBD and whether it eases caregiver burden.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07844655

• Personalized magnetic brain stimulation for parkinsonian disorders

  This study will try personalized repetitive transcranial magnetic stimulation (rTMS) to see if it eases motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07570212

• tDCS to improve walking and movement in PSP, corticobasal syndrome, and Parkinson's disease

  The study will try applying gentle brain stimulation (tDCS) during walking practice to see if it improves gait, speech, eye movements, and hand dexterity in people with PSP, corticobasal syndrome, or Parkinson's disease.

  Recruiting Baycrest · Toronto, Ontario · NCT07291687

• ARO-MAPT-SC in healthy adults and people with early Alzheimer's disease

  This trial will test whether ARO-MAPT-SC is safe, tolerable, and produces the expected drug levels and biomarker effects in healthy adults and people with early Alzheimer's disease.

  Recruiting at 4 sites Phase 1/2 Arrowhead Pharmaceuticals · East York, Ontario and 3 other locations · NCT07221344

• Genetic program for Progressive Supranuclear Palsy and related conditions

  This study is collecting DNA from adults with Progressive Supranuclear Palsy and similar conditions to see how genetics might help improve diagnosis and care for patients.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06647641

• Examining health services and quality of life in patients with atypical Parkinsonian syndromes

  This study looks at how people with atypical Parkinsonian syndromes, like progressive supranuclear palsy and multiple system atrophy, use health services and how their quality of life is affected by having access to specialist clinics and support services.

  Recruiting University Hospital Southampton NHS Foundation Trust · Southampton, Hampshire · NCT06645626

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Using a non-invasive device to help manage symptoms in people with Parkinson's disease

  This study is testing a new device that uses gentle vibrations to see if it can help people with Parkinson's disease feel better and manage their symptoms.

  Recruiting Queen Mary University of London · London · NCT06174948

• NAD replenishment therapy for atypical parkinsonism

  This study is testing if taking a supplement called Nicotinamide Riboside can help people with atypical parkinsonism feel better and slow down their symptoms.

  Recruiting at 3 sites Phase 2 Haukeland University Hospital · Oslo, Oslo and 2 other locations · NCT06162013

• Assessing swallowing function in patients with neurodegenerative diseases

  This study looks at how well people with neurodegenerative diseases, like Parkinson's and Motor Neuron Disease, can swallow and how it affects their quality of life.

  Recruiting at 16 sites Kliniken Beelitz GmbH · Innsbruck, Tyrol and 15 other locations · NCT04706234

• Neurodegenerative Diseases Registry

  This registry collects data from adults with neurodegenerative conditions to help doctors distinguish between Parkinsonian syndromes and related disorders and understand disease progression over time.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04472130

• Using neuroimaging to improve diagnosis and prognosis of Parkinson's disease and related conditions

  This study is trying to find brain imaging markers that can help doctors better diagnose and predict how Parkinson's disease and similar conditions will progress in patients.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03872102

• Understanding neurodegenerative disorders like ALS and frontotemporal dementia

  This study is trying to see if adults with neurodegenerative disorders like ALS and frontotemporal dementia can join future research by checking their health and collecting samples for further testing.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03225144

• A study on early diagnosis and biomarkers for dementia and related diseases

  This study is testing new ways to spot dementia and related diseases early by looking for specific markers in the brain and body, to help people at high risk and track how well new treatments are working.

  Recruiting at 2 sites Skane University Hospital · Ängelholm and 1 other locations · NCT03174938

• Diagnosing frontotemporal lobar degeneration

  This study is testing different ways to diagnose frontotemporal lobar degeneration to help doctors identify the condition more accurately.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT02964637

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

• Analyzing tau levels in the brain of patients with Progressive Supranuclear Palsy

  This study is testing a special imaging tool to see how much tau protein builds up in the brains of people with Progressive Supranuclear Palsy to help understand the condition better.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02605785

• Identifying factors that improve quality of life in Parkinson's disease

  This study is trying to find out what lifestyle choices and habits can help people with Parkinson's disease feel better and improve their quality of life.

  Recruiting Bastyr University · Kenmore, Washington · NCT02194816

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Imaging brain changes over time in progressive supranuclear palsy

  This project uses repeated brain scans to track disease-related changes over time in people with progressive supranuclear palsy.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11299639

• Tau’s effect on protein production in Alzheimer’s and PSP

  This grant investigates how abnormal tau protein disrupts the way cells make proteins, which may contribute to memory problems in Alzheimer’s disease and PSP.

  NIH research University of Florida · Gainesville, United States · NIH-11215570

• Platform to try new treatments for progressive supranuclear palsy

  This project will compare three medicines for people with mild to moderate progressive supranuclear palsy to learn if they are safe and help symptoms.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11160498

• Investigating tau protein accumulation and its effects on movement in brain injuries.

  This study is looking at how repeated head injuries might lead to movement problems, like those seen in Parkinson's disease, by examining changes in the brain after someone has passed away, and it aims to find clues that could help diagnose these issues better for people affected by chronic traumatic encephalopathy (CT

  NIH research Boston University Medical Campus · Boston, United States · NIH-11085161

• Using brain stimulation to improve balance in patients with progressive supranuclear palsy

  This study is looking at a safe and painless way to use brain stimulation to help people with progressive supranuclear palsy (PSP) improve their balance and reduce the risk of falling, so they can stay active and independent for longer.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11074107

• Understanding walking and balance problems in a rare neurological condition.

  This study is looking at how walking and balance problems affect people with progressive supranuclear palsy (PSP) and aims to create better ways to measure these issues so that patients can receive improved care and support.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10912445

• Investigating tau protein accumulation in the brain related to Progressive Supranuclear Palsy.

  This study is looking at how a protein called tau builds up in certain parts of the brain and how that might lead to Progressive Supranuclear Palsy (PSP), with the goal of finding early signs of the disease and better ways to diagnose and treat it.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-10795724

• Testing new treatments for Progressive Supranuclear Palsy.

  This study is creating a new way to test different treatments for Progressive Supranuclear Palsy (PSP) to see how safe and effective they are, and it’s for people living with PSP who want to help find better therapies.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10784249

• A new zebrafish model to study balance issues in progressive supranuclear palsy

  This study is exploring a new way to understand progressive supranuclear palsy (PSP) by using zebrafish to mimic the brain changes that happen in this condition, which could help researchers find better treatments for people with PSP.

  NIH research New York University School of Medicine · New York, United States · NIH-10764950

Related topics

Quick answers

How many Progressive Supranuclear Palsy clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (7 trials), Canada (5 trials), United Kingdom (2 trials), Austria (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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