Condition

Dementia With Lewy Bodies clinical trials and research

• 16Clinical trials
• 17NIH research projects
• 11Countries

Newest Dementia With Lewy Bodies clinical trials

All recruiting trials (16)

• Red-light helmet therapy for people with dementia with Lewy bodies

  This test will see if red-light therapy worn as a helmet can help improve thinking, daily life, and brain activity in people with DLB.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07602296

• Cholinergic degeneration and cognitive fluctuations in Lewy body dementias

  This project will test whether loss of cholinergic neurons is linked to cognitive fluctuations in people with Lewy body dementias using blood and skin biomarkers, multimodal MRI, prolonged EEG, and will try an 8‑week galantamine treatment in a small subgroup.

  Recruiting Phase 4 Virginia Commonwealth University · Richmond, Virginia · NCT07284290

• Magnetic stimulation of the visual cortex to try to improve thinking in dementia with Lewy bodies

  This trial will try repetitive transcranial magnetic stimulation (rTMS) over the back of the head to see if it improves thinking and memory in people aged 65 and older with dementia with Lewy bodies.

  Recruiting Phase 1/2 Korea University Anam Hospital · Seoul, Seoul · NCT07122908

• Predicting disease progression in dementia using biomarkers and modeling

  This study is trying to create a tool that helps predict how dementia will progress in people with mild cognitive impairment and different types of dementia, like Alzheimer's and Lewy Body Disease, by looking at brain scans, body fluids, and mental tests.

  Recruiting University Health Network, Toronto · North York, Ontario and 3 other locations · NCT06529744

• Comparing imaging techniques for diagnosing Parkinson's disease and related conditions

  This study is testing two different imaging techniques to see which one better helps doctors tell apart Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, and Alzheimer's disease in patients and healthy volunteers.

  Recruiting at 2 sites Phase 2/3 Universitaire Ziekenhuizen KU Leuven · Ghent, Gent and 1 other locations · NCT06120049

• Evaluating a new PET imaging agent for brain conditions

  This study is testing a new imaging agent to see if it can help detect certain brain changes in people with Parkinson's disease, Multiple System Atrophy, and Dementia with Lewy Bodies, as well as in healthy individuals.

  Recruiting Early Phase 1 Massachusetts General Hospital · Charlestown, Massachusetts · NCT06098612

• Comparing two medications for treating psychosis in Parkinson's disease and dementia with Lewy bodies

  This study is testing which of two medications, pimavanserin or quetiapine, works better to help people with psychosis caused by Parkinson's disease or dementia with Lewy bodies.

  Recruiting at 2 sites Phase 4 The University of Texas Health Science Center at San Antonio · San Antonio, Texas and 1 other locations · NCT05590637

• Using light to study brain function in dementia

  This study is trying to see how light can help us understand changes in brain function for people with different types of dementia and healthy individuals.

  Recruiting University of Cambridge · Cambridge · NCT05460143

• Non-invasive brain stimulation for neurodegenerative diseases

  This study is testing if a new type of brain stimulation can help relieve symptoms in people with neurodegenerative diseases like Alzheimer's and dementia.

  Recruiting Kuopio University Hospital · Kuopio · NCT05326750

• Observational study of dementia in elderly Chinese patients

  This study looks at older Chinese adults with dementia to see how lifestyle and stress affect their condition and to track their cognitive health over time.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT05023564

• Collection of cerebrospinal fluid for cognitive disorder research

  This study is collecting spinal fluid from people with cognitive disorders like Alzheimer's and dementia to help improve how these diseases are diagnosed.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT04844060

• Investigating ambroxol for early dementia with Lewy bodies

  This study is testing if ambroxol can help people with early dementia with Lewy bodies improve their thinking skills and overall well-being.

  Recruiting at 8 sites Phase 2 Helse Fonna · Haugesund, Haugesund and 7 other locations · NCT04588285

• Improving cognitive outcomes in patients with sleep apnea using home testing

  This study is trying to see if home testing for sleep apnea can help diagnose the condition better in people with cognitive issues like Alzheimer's, making it easier for them to get the treatment they need.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT04335994

• Imaging with [18F]F-DOPA in patients with autonomic failure

  This study is testing a special imaging technique to see if it can help identify early signs of neurodegenerative diseases in people with autonomic failure.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04246437

• Identifying factors that improve quality of life in Parkinson's disease

  This study is trying to find out what lifestyle choices and habits can help people with Parkinson's disease feel better and improve their quality of life.

  Recruiting Bastyr University · Kenmore, Washington · NCT02194816

• Observing the progression of synucleinopathies

  This study is tracking how synucleinopathies, a group of brain diseases, progress in adults with symptoms like dizziness when standing up to better understand their development over time.

  Recruiting at 8 sites NYU Langone Health · Boston, Massachusetts and 7 other locations · NCT01799915

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how heparan sulfate affects alpha-synuclein in Lewy body dementia

  A small study in people who have dementia with Lewy bodies looks at how a brain sugar (heparan sulfate) helps a harmful protein (alpha-synuclein) spread, with the hope of slowing disease progression.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11606576

• Alpha-synuclein seed test in blood or urine for Parkinson’s and Lewy body diseases

  A new blood or urine test using seed amplification to help diagnose Parkinson’s disease, dementia with Lewy bodies, and related conditions earlier and more clearly.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11443945

• Dementia with Lewy Bodies Consortium

  A national research effort to better understand and diagnose Lewy body dementia by studying biomarkers and patient data over time.

  NIH research Seattle Inst for Biomedical/clinical Res · Seattle, United States · NIH-11412709

• Rat model of dementia with Lewy bodies may help us study memory and movement problems

  A scientist team is creating and validating a rat model that mirrors Dementia with Lewy Bodies to better understand how it develops and to test potential treatments.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11357724

• Proof of Concept Study on Clinical Trial Outcomes and Biomarkers in Early Lewy Body Dementia

  A small, early-stage study is testing whether new biomarkers and trial outcomes can better measure symptoms and treatment effects for people with Lewy body dementia.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11341276

• Amyloid-clearing therapy for dementia with Lewy bodies plus Alzheimer's disease

  A study tests an amyloid-clearing antibody in people who have both Dementia with Lewy bodies and Alzheimer's disease to see if it can safely help with their symptoms.

  NIH research Stanford University · Stanford, United States · NIH-11264576

• New method to deliver treatments for dementia with Lewy bodies

  This study is exploring a new way to deliver special treatments that can help reduce harmful proteins linked to dementia, using a friendly peptide to help get these treatments into the brain more easily, with the goal of making therapies safer and more effective for people with dementia.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11230055

• Understanding Brain Energy Problems in Dementia with Lewy Bodies

  This project explores how energy problems in the brain contribute to Dementia with Lewy Bodies, aiming to uncover new ways to help patients.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11092730

• Investigating a new treatment for dementia with Lewy bodies

  This study is looking at how well a new oral medication called neflamapimod can help improve thinking and movement problems in people with mild-to-moderate dementia with Lewy bodies, a condition that currently has no approved treatments.

  NIH research Eip Pharma, INC. · Boston, UNITED STATES · NIH-11019686

• Investigating genetic factors affecting brain protein accumulation in dementia and Parkinson's disease

  This study is looking at how certain genes might affect the severity of symptoms in people with dementia with Lewy bodies and Parkinson's disease, helping us understand why some folks have worse symptoms than others, even if their genes are similar.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10999445

• Improving treatments for dementia with Lewy bodies and Parkinson’s disease-dementia

  This study is looking into how certain proteins and cell functions are linked to dementia with Lewy bodies and Parkinson’s disease-dementia, hoping to find new ways to help improve memory and daily life for patients.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10936681

• Understanding Balance Problems in Aging and Lewy Body Dementia

  This project aims to understand why older adults, especially those with Lewy Body Dementia, have trouble with balance and are at high risk for falls.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10928127

• Understanding end-of-life experiences in dementia with Lewy bodies

  This study is looking at what affects the end-of-life experiences for people with dementia with Lewy bodies and their caregivers, so we can help families get better support and information during this tough time.

  NIH research University of Florida · Gainesville, United States · NIH-10831486

• Understanding balance issues in older adults with dementia

  This study is looking at how aging and Dementia with Lewy Bodies affect balance and the chances of falling in older adults, so we can better understand how to help keep them steady on their feet.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10749539

• Understanding early signs of dementia with Lewy bodies

  This study is looking at the early signs of dementia with Lewy bodies to help doctors spot it more easily and quickly, so if you or someone you know is experiencing these symptoms, this research could lead to better ways to diagnose and treat this condition.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10670501

• A test to differentiate between dementia with Lewy Bodies and Alzheimer's disease

  This study is testing a new diagnostic test to help doctors tell the difference between dementia with Lewy Bodies and Alzheimer's disease, so that people can get the right treatment and care they need.

  NIH research Cnd Life Sciences, INC. · Scottsdale, UNITED STATES · NIH-10589126

• Investigating brain changes in Lewy Body dementia and Parkinson's disease dementia using patient-derived neurons.

  This study is looking at how dementia with Lewy bodies and Parkinson's disease dementia are different by examining brain cells from people who had these conditions, which could help doctors find better ways to diagnose and treat them.

  NIH research St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-10511261

Related topics

Quick answers

How many Dementia With Lewy Bodies clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (6 trials), France (2 trials), Canada (2 trials), South Korea (2 trials), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Early Phase 1: 1, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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