Investigating how a specific immune response contributes to brain damage in a mouse model of multiple system atrophy.
Official title: Interferon-gamma mediates neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy (MSA)
Funded at Yale University · NIH-10856291 · Data updated 2026-11-12
This study is looking at how a protein called interferon-gamma affects the progression of multiple system atrophy (MSA) by exploring its role in inflammation and nerve damage, which could help us find new treatments for people with MSA.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 20, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $86,190 |
| NIH project number | 4K00NS129106-02 |
| Project ID | NIH-10856291 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple system atrophy or those at risk for developing this condition.
✕Less likely to help
Patients with other neurodegenerative diseases that do not involve similar immune mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding the role of interferon-gamma (IFNγ) in the progression of multiple system atrophy (MSA), a severe neurodegenerative disease. Using a mouse model that mimics MSA, the study examines how IFNγ influences neuroinflammation and demyelination, which are key features of the disease. By analyzing the immune response, particularly the activity of CD4+ T cells, the research aims to clarify the mechanisms behind MSA pathology. Patients may benefit from insights gained into the immune processes involved in MSA, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that target immune responses to slow or halt the progression of multiple system atrophy.
How similar studies have gone: Previous research has shown promising results in understanding immune mechanisms in other neurodegenerative diseases, suggesting that this approach may yield valuable insights for MSA as well.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Corbin-Stein, Nicole — Yale University
- Study coordinator: Corbin-Stein, Nicole
Related research
Other NIH-funded projects on the same topics.
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Integrated MRI biomarkers to diagnose and monitor multiple system atrophy
This project will help doctors use MRI markers to better diagnose multiple system atrophy and track how the disease progresses.
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Clinical Trial Readiness for Multiple System Atrophy
A multi-center study to help people with multiple system atrophy by creating better clinical and biological measures to use in future drug trials.
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Single-cell brain profiling to map MSA cell changes
Researchers will map gene activity in individual brain cells from people who had multiple system atrophy to understand how the disease affects cells in key brain regions.
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Investigating how inflammation caused by alpha-synuclein affects multiple system atrophy
This study is looking at how inflammation affects multiple system atrophy (MSA) and aims to understand how the immune system might play a role in the disease, with the hope of finding new ways to help people with MSA.
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Understanding brain inflammation in multiple system atrophy
This research explores how a specific immune signal, interferon-gamma, contributes to brain damage in multiple system atrophy.
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Single-cell gene map of brains from people with multiple system atrophy
This project reads gene activity in individual brain cells from people with multiple system atrophy to find cell-specific changes linked to the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.