Investigating how a specific immune response contributes to brain damage in a mouse model of multiple system atrophy.
Interferon-gamma mediates neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy (MSA)
This study is looking at how a protein called interferon-gamma affects the progression of multiple system atrophy (MSA) by exploring its role in inflammation and nerve damage, which could help us find new treatments for people with MSA.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10856291 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of interferon-gamma (IFNγ) in the progression of multiple system atrophy (MSA), a severe neurodegenerative disease. Using a mouse model that mimics MSA, the study examines how IFNγ influences neuroinflammation and demyelination, which are key features of the disease. By analyzing the immune response, particularly the activity of CD4+ T cells, the research aims to clarify the mechanisms behind MSA pathology. Patients may benefit from insights gained into the immune processes involved in MSA, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple system atrophy or those at risk for developing this condition.
Not a fit: Patients with other neurodegenerative diseases that do not involve similar immune mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that target immune responses to slow or halt the progression of multiple system atrophy.
How similar studies have performed: Previous research has shown promising results in understanding immune mechanisms in other neurodegenerative diseases, suggesting that this approach may yield valuable insights for MSA as well.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Corbin-Stein, Nicole — Yale University
- Study coordinator: Corbin-Stein, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.