Condition

Keratoconus clinical trials and research

• 27Clinical trials
• 11NIH research projects
• 20Countries

Newest Keratoconus clinical trials

All recruiting trials (27)

• Corneal Crosslinking to Treat Progressive Keratoconus or Corneal Ectasia

  This study tests two different light durations used in corneal crosslinking to see which better helps people with keratoconus or corneal ectasia.

  Recruiting Phase 2/3 Price Vision Group · Indianapolis, Indiana · NCT07841470

• Brillouin hydration mapping to study cornea health

  Researchers test a Brillouin microscope to see if it can measure corneal water content in healthy people and those with eye conditions.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07780890

• Same-day bilateral corneal cross-linking for keratoconus

  This trial tests whether performing corneal cross-linking in both eyes on the same day is safe and feasible for people with keratoconus.

  Recruiting Phase 4 Glaukos Corporation · Westerville, Ohio · NCT07629557

• A Smart Aperture Lens to Help Keratoconus and Presbyopia

  This study tests the NOA lens, a custom scleral contact lens with a central aperture, to see if it improves vision for people with keratoconus and presbyopia.

  Recruiting at 2 sites Azalea Vision · Antwerp and 1 other locations · NCT07559188

• GLK-221 eye drops for keratoconus

  This trial will test whether twice-daily GLK-221 eye drops are safe and help adults aged 18–55 with keratoconus compared with a placebo.

  Recruiting Phase 2 Glaukos Corporation · Westerville, Ohio · NCT07400952

• Corneal wavefront-guided PRK plus epi-off CXL versus PTK plus epi-off CXL for keratoconus

  This trial tests whether adding corneal wavefront-guided PRK to epi-off corneal cross-linking gives better vision than PTK plus epi-off CXL in adults with keratoconus.

  Recruiting Instituto de Oftalmología Fundación Conde de Valenciana · Mexico City, Mexico City · NCT07372911

• Epi-ON corneal crosslinking with UVA for people with Down syndrome and corneal ectasia

  This trial will try Epi-ON corneal crosslinking (riboflavin drops plus UVA light) to see if it can slow or stop corneal thinning and vision loss in people with Down syndrome who have keratoconus or similar ectatic corneal conditions.

  Recruiting at 12 sites Phase 3 Woolfson Eye Institute · Atlanta, Georgia and 11 other locations · NCT07135167

• Epi-ON corneal crosslinking: 18-minute versus 24-minute UVA exposure for ectatic corneas

  This test compares whether an 18-minute or a 24-minute Epi-ON corneal crosslinking procedure better slows progression in people with keratoconus or other ectatic corneal conditions.

  Recruiting at 12 sites Phase 3 Woolfson Eye Institute · Atlanta, Georgia and 11 other locations · NCT07124910

• Corneal versus scleral rigid gas permeable lenses for keratoconus

  This trial tests corneal versus scleral rigid gas permeable lenses in adults with keratoconus to see which lens type gives better vision and comfort.

  Recruiting University of Aarhus · Aarhus · NCT06921967

• Understanding keratoconus in children

  This study looks at the signs and causes of keratoconus in children to see how it differs from adults and to better understand this eye condition that can affect vision.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT06722937

• Implantable device for treating advanced keratoconus

  This study is testing a new implant for people with advanced keratoconus to see if it can improve their vision when other treatments aren't an option.

  Recruiting Recornea Srl · Roma, Roma and 1 other locations · NCT06451718

• Combining two treatments for keratoconus to improve vision

  This study is testing if combining two treatments for keratoconus can help improve vision more than just one treatment alone.

  Recruiting Oslo University Hospital · Oslo · NCT06264024

• Understanding risk factors and progression of keratoconus

  This study is trying to see how keratoconus changes over two years in 200 people with different treatment options, including no treatment, to better understand the condition and its effects.

  Recruiting University Hospital, Montpellier · Montpellier, Occitanie · NCT05676580

• Evaluating a new system for cornea crosslinking in patients with cornea thinning

  This study is testing a new system for treating cornea thinning in people with keratoconus to see if it is safe and effective.

  Recruiting Phase 2 Cohen Laser and Vision Center · Boca Raton, Florida · NCT05516004

• Evaluation of a new corneal implant for severe eye conditions

  This study is testing a new corneal implant to see if it can help people with severe eye conditions like keratoconus and post-LASIK ectasia improve their vision without needing more invasive surgery.

  Recruiting The Royal Wolverhampton Hospitals NHS Trust · Wolverhampton, West Midlands · NCT04741230

• Optimizing scleral lens fittings using advanced imaging technology

  This study is testing if using advanced imaging technology can help fit scleral contact lenses better for people with keratoconus and other corneal issues.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT04570020

• Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking

  This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04439552

• Long-term follow-up for patients with corneal diseases

  This study looks at how well different treatments work for people with corneal diseases like keratoconus over the long term, to see how their eyes are doing after surgery.

  Recruiting Technische Universität Dresden · Dresden, Saxony · NCT04251143

• Advanced imaging techniques for eye conditions

  This study is testing new advanced imaging techniques to see if they can help doctors better understand and diagnose eye diseases like retinitis pigmentosa and maculopathy.

  Recruiting Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts · Paris · NCT04129021

• Evaluating a new system for treating corneal ectasia

  This study is testing a new treatment system for people with corneal ectasia and keratoconus to see if it can help improve their eye health and vision.

  Recruiting Phase 2 Goodman Eye Center · San Francisco, California · NCT04094090

• Longitudinal analysis of Keratoconus patients at the Homburg Keratoconus Center

  This study looks at over 3,000 people with Keratoconus to see how the disease develops over time and to find ways to improve diagnosis and treatment.

  Recruiting Universität des Saarlandes · Homburg, Saarland · NCT03923101

• Improving vision in keratoconus using laser collagen cross-linking

  This study is testing a new way to use laser treatment to improve vision in people with keratoconus by using special imaging to make the procedure more precise.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT03760432

• Using OCT to Diagnose Irregular Corneas

  This study is testing a new way using advanced imaging to better identify and track irregular corneas in people with conditions like keratoconus, to help improve their treatment.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT03504800

• Global assessment of keratoconus prevalence in children and adolescents

  This study is trying to find out how common keratoconus is in kids and teens around the world by using special eye imaging techniques.

  Recruiting at 10 sites University Hospital, Geneva · Los Angeles, California and 11 other locations · NCT03115710

• Measuring corneal properties to predict treatment outcomes

  This study is testing new ways to measure the shape and strength of the cornea to see if it can help predict how well treatments like LASIK will work for people with keratoconus or those needing eye surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03030755

• Treatment for Keratoconus with INTACS Inserts

  This study is testing whether using special inserts in the eyes can help people with keratoconus see better by reshaping their corneas.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT02138669

• Testing Brillouin Microscopy for Diagnosing Corneal Conditions

  This study is testing a new imaging technique called Brillouin microscopy to see if it can better diagnose corneal issues like keratoconus and ectasia in people.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT02118922

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Engineered Cornea Chip to Study Keratoconus Curvature

  A patient-friendly model of keratoconus will be created on a tiny, engineered eye chip to study how shape changes affect eye tissue and to identify potential new treatments.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11450784

• How hormones and the pituitary may affect keratoconus

  This project looks at whether sex hormones and pituitary signals change the cornea in people with keratoconus to help explain why the disease starts and progresses.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11262874

• Cell and genetic causes of keratoconus

  Researchers are analyzing cell changes and genes in people with keratoconus to find early warning signs and new treatment targets.

  NIH research New York University School of Medicine · New York, United States · NIH-11262821

• Wide-view cornea imaging to detect keratoconus

  This project is building a wide-field corneal OCT scan to spot tiny early changes in the cornea in people with or at risk for keratoconus.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11250039

• Exploring the connection between keratoconus and sex hormones

  This study is looking at how sex hormones might affect keratoconus, an eye condition that can worsen vision, to help find better ways to manage it and improve care for people dealing with this issue.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11012315

• Improving early detection of keratoconus using advanced imaging technology

  This study is testing a new imaging technology that helps doctors spot keratoconus earlier by taking detailed pictures of the eye's surface, which could lead to better treatment and help protect your vision.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11004118

• Preventing cell death in corneal cells to treat keratoconus without surgery

  This study is looking for new ways to help people with keratoconus, a condition that affects vision by thinning the cornea, by finding treatments that can keep important cells in the eye alive and healthy.

  NIH research Harvard Medical School · Boston, United States · NIH-10917275

• Creating a realistic 3D model of the human cornea for keratoconus treatment

  This study is creating a detailed 3D model of the eye's cornea to help us understand keratoconus better, which could lead to better treatments and tools for people dealing with this vision loss condition.

  NIH research Cfd Research Corporation · Huntsville, United States · NIH-10821906

• Investigating a new biomarker for keratoconus

  This study is looking at a protein called PIP to see if it can help doctors diagnose keratoconus earlier and improve treatment options for people with this eye condition.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-10723125

• Investigating a new biomarker for keratoconus

  This study is looking at a protein called PIP to see if it can help doctors spot keratoconus earlier and improve treatment options for people with this eye condition.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-10653013

• New eyedrop treatment for keratoconus

  This study is testing a new eyedrop treatment for people with keratoconus to help strengthen the cornea and improve vision, so they might avoid more serious procedures like corneal transplants.

  NIH research Iveena Delivery Systems, INC. · Salt Lake City, United States · NIH-10245284

Related topics

Quick answers

How many Keratoconus clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (16 trials), Germany (3 trials), China (2 trials), Mexico (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 4: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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